THE PHENOMENOLOGY AND TREATMENT OF OBESSIVE-COMPULSIVE DISORDER IN ADULTS

成人强迫症的现象和治疗

• 批准号: 3845156
• 负责人: D L MURPHY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3845156
• 关键词: adult human (21+); anorexia nervosa; anxiety; blood chemistry; bulimia nervosa; catecholamines; corticotropin releasing factor; eating disorders; hormone regulation /control mechanism; human morbidity; human subject; human therapy evaluation; neuroendocrine system; neurotransmitter metabolism; nutrition related tag; obsessive compulsive disorder; psychobiology; serotonin; serotonin receptor; vasopressins

In studies of obsessive-compulsive disorder (OCD) co-morbidity, 59 OCD patients were found to have a substantial overlap in eating disorder-related symptoms, with intermediate eating disorder inventory scores between patients with anorexia nervosa or bulimia nervosa and healthy controls. Patients with the focal dystonia, blepharospasm, were found to share significantly more OCD-related symptoms than healthy controls. In psychobiologic studies, OCD patients exhibited no differences in arterial plasma catecholamine concentrations compared to healthy controls when both groups were sampled over time in an anxietyinducing situation - a finding congruent with other data that continue to reveal more serotonin-related abnormalities than other neurotransmitter system differences in OCD patients. In one of the first studies of neuropeptides in this disorder, patients with OCD were found to have abnormalities in the regulation of vasopressin and corticotrophin releasing factor secretion.

在强迫症（OCD）合并症的研究中，59 OCD 发现患者在饮食中有很大的重叠 与障碍有关的症状，中等饮食失调症清单 神经性厌食症或神经性贪食症患者与 健康控制。 患有局灶性肌张力障碍的患者，骨痉挛，是 发现与健康相关的OCD相关症状明显多 控件。 在心理生物学研究中，强迫症患者在 与健康对照相比，动脉血浆儿茶酚胺浓度 当两组在焦虑的​​情况下随时间取样时 - 与其他数据继续揭示更多数据一致的发现 与其他神经递质系统相比，5-羟色胺相关的异常 强迫症患者的差异。 在最初的研究之一 这种疾病中的神经肽，发现强迫症患者患有 加压素和皮质营养素的调节异常 释放因子分泌。