Stability of cognitive performance in anorexia nervosa

神经性厌食症认知表现的稳定性

• 批准号: 6542739
• 负责人: BRADLEY D MCDOWELL
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2004-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6542739
• 关键词: adolescence (12-20); adult human (21+); anorexia nervosa; anxiety; attention; cerebral dominance; cognition; compulsive behavior; depression; functional ability; human subject; longitudinal human study; neuropsychological tests; neuropsychology; patient /disease registry; patient oriented research; psychological tests

Preliminary research suggests that the cognitive of patients with anorexia nervosa (AN) improve over the course of inpatient treatment. The psychological and physiological factors that are associated with improvement of cognitive abilities one year after discharge will be determined. Funding of this project will also provide the resources needed to organize a database of patients with eating disorders to be recruited for subsequent research projects. The primary hypothesis that cognitive abilities measured one year after discharge will be significantly associated with the severity of AN symptoms. If AN severity worsens from post-treatment levels, the gains made during inpatient treatment will decay; if AN severity improves, the gains made during inpatient treatment will be further enhanced. Other predictors of cognitive improvement will be evaluated. Specifically, we will look at baseline and post-treatment levels of depression and anxiety, obsessive measures, and general functioning as they relate to neuropsychological performance at baseline, post-treatment, and follow- up. The results will allow the stability of cognitive performances to be determined, and allow the relationship between neuropsychological test results and the core AN psychopathology to be clearly defined. Such findings could provide to be quite clinically useful. Likewise, practitioners should know whether these skills stabilize after hospitalization or if they require more frequent monitoring. Such information also informs our basic understanding of how the brain recovers from the effects of starvation.

初步研究表明，在住院治疗过程中，神经性厌食症（AN）患者的认知得到改善。出院后一年后，与认知能力提高相关的心理和生理因素将得到确定。该项目的资金还将提供组织饮食失调患者数据库所需的资源，以招募随后的研究项目。出院后一年测得的认知能力的主要假设将与症状的严重程度显着相关。如果治疗后的严重程度恶化，住院治疗期间的收益将衰减；如果严重程度提高，则在住院治疗期间取得的收益将进一步增强。将评估认知改善的其他预测指标。具体而言，我们将研究抑郁和焦虑，强迫措施的基线和治疗后水平，以及与基线，治疗后和随访相关的神经心理学表现时的一般功能。结果将允许确定认知表现的稳定性，并可以明确定义神经心理学测试结果与核心心理病理学之间的关系。这样的发现可以提供临床上有用的。同样，从业者应该知道这些技能在住院后是否稳定，还是需要更频繁的监测。此类信息还为我们对大脑如何从饥饿的影响中恢复的基本了解提供了信息。