NEUROPHARMACOLOGY OF NEUROENDOCRINE AND NEUROTRANSMITTER REGULATORY MECHANISMS

神经内分泌和神经递质调节机制的神经药理学

• 批准号: 3880833
• 负责人: D L MURPHY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880833
• 关键词: MAO inhibitors; Macaca mulatta; adrenergic agents; antibody; antidepressants; blood chemistry; blood pressure; cerebrospinal fluid; chromosome deletion; drug administration routes; genetics; hormone regulation /control mechanism; human subject; human tissue; neural information processing; neuroanatomy; neuroendocrine system; neuropharmacology; neurotransmitter metabolism; neurotransmitter receptor; neurotransmitters; piperazines; psychophysiology; serotonin; serotonin inhibitor; serotonin receptor; tissue /cell culture; MAO inhibitors; Macaca mulatta; adrenergic agents; antibody; antidepressants; blood chemistry; blood pressure; cerebrospinal fluid; chromosome deletion; drug administration routes; genetics; hormone regulation /control mechanism; human subject; human tissue; neural information processing; neuroanatomy; neuroendocrine system; neuropharmacology; neurotransmitter metabolism; neurotransmitter receptor; neurotransmitters; piperazines; psychophysiology; serotonin; serotonin inhibitor; serotonin receptor; tissue /cell culture

In the past year, this project has chiefly focused on investigations of the functional status of the serotonin (5-HT) neurotransmitter system in humans using 5-HT-selective agonists and antagonists as pharmacologic probes. Psychophysiologic responses to the 5-HT agonist, m-chlorophenylpiperazine (m-CPP), including blood pressure, neuroendocrine measures, temperature, and subjectively-assessed as well as objectively-rated behavioral changes, have been found to be differentially altered in different neuropsychiatric patient subgroups. Those differences in responsivity have also been found to differ according to dose and route of administration of M-CPP. Many other examples of differential responses to other serotonin agonists and antagonists support the concept that humans as well as other species have functionally different, independently modulated serotonergic subsystems which appear to correspond, at least in part, to the heterogeneous 5-HT binding sites and neuroanatomical subpathways identified in vivo.

在过去的一年中，该项目主要集中于调查 人类5-羟色胺（5-HT）神经递质系统的功能状态 使用5-HT选择性激动剂和拮抗剂作为药理探针。 对5-HT激动剂M-氯苯基哌嗪的心理生理反应 （M-CPP），包括血压，神经内分泌测量，温度， 并主观评估以及客观评价的行为改变， 已经发现在不同的神经精神病学中有差异性改变 患者亚组。这些响应性上的差异也已被发现 根据M-CPP的剂量和给药途径有所不同。许多 其他对其他5-羟色胺激动剂的不同反应的例子 对手支持人类以及其他物种具有的概念 功能不同，独立调制的血清素能子系统 似乎至少部分与异质5-HT相对应 结合位点和神经解剖学亚路径在体内鉴定出来。