ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

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• 批准号: 3105056
• 负责人: IRMA GIGLI
• 金额: $ 34.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105056
• 关键词: human subject; hypersensitivity; skin hypersensitivity; urticaria

Continuation of support is requested for a multidisciplinary center to study the basic pathologic mechanisms of certain skin diseases which appear to have the participation of humoral or cellular immunologic events, either as a primary or secondary manifestation. The center will concentrate in studies of: 1. Diseases within the spectrum of cutaneous vasculitis-angioedema-urticaria. In these studies we will attempt to identify the biochemical mediators and cellular interactions that may be responsible for the clinical manifestations in this group of diseases. 2. Receptors in patients presenting with clinical manifestations within the spectrum of altered immunologic reactivity. These studies will involve patients with: acquired deficiency syndrome, lupus erythematosus and Hansen's disease. It is proposed that complement receptors may be predictive markers of disease activity. 3. Phototoxic reactions either due to genetic defects in phorphyrin metabolism or intake of medications. These diseases offer an excellent model for studies of non-immunologic activation of the complement system and mast cell derived mediators.

要求继续支持多学科中心 研究某些皮肤疾病的基本病理机制 要参加体液或细胞免疫学事件的参与 作为主要或次要表现。 中心将集中在 研究： 1。皮肤频谱中的疾病 血管炎血管水肿。 在这些研究中，我们将尝试 确定可能是的生化介质和细胞相互作用 负责这组疾病中的临床表现。 2。出现在临床表现的患者的受体 免疫反应性改变的频谱。 这些研究将涉及 患者：获得性缺乏综合征，红斑狼疮和 汉森病。 有人提出补体受体可能是 疾病活动的预测标记。 3。光毒性反应要么由于苯丁胺的遗传缺陷而引起 代谢或药物摄入。 这些疾病提供了极好的 补体系统非免疫学激活的研究模型 和肥大细胞得出的介体。