ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

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• 批准号: 3105055
• 负责人: IRMA GIGLI
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105055
• 关键词: asthma; human subject; hypersensitivity

Support is requested for the establishment and maintenance of a multidisciplinary center for the study of immunologic mechanisms which may play a role in the pathogenesis of certain cutaneous diseases. Such a center will harness the combined efforts of dermatologists, immunologists and allergists from various departments in the University of California, San Diego. This application is directed to three areas of research relevant to skin diseases: (a) Immunoregulatory mechanisms in patients with a variety of skin diseases thought to be immunologic in nature, (b) metabolic and biochemical alterations in immunologically damaged skin and (c) regulation of cell traffic in the epidermis and relation to the Langerhans cell. Because of their prevalence and relevance, the specific diseases to be studied include leukocytoclastic vasculitis, drug eruptions, urticaria and atopic dermatitis. Cutaneous phototoxic reactions mediated either by drugs or by endogenous phototoxic chemicals (prophyrias) offer excellent models to study tissue damage produced by activation of the complement system and the subsequent release of chemical mediators. The question of whether Langerhans cells have a "trophic" function for lymphoid cells will be investigated. Its role in vivo will be evaluated by assessing its involvement in a variety of skin diseases in which a cell-mediated immunologic mechanism seems to be involved. These studies may help not only to further our knowledge in this area, but will serve in the development of new therapeutic approaches.

要求建立和维护 免疫机制研究的多学科研究中心 在某些皮肤病的发病机理中发挥作用。 这样的 中心将利用皮肤科医生，免疫学家的综合努力 以及来自加利福尼亚大学各个系的过敏症分子 圣地亚哥。 该应用程序针对三个研究领域 与皮肤疾病有关：（a）患者的免疫调节机制 具有多种皮肤疾病本质上是免疫学的，（b） 免疫学损害皮肤的代谢和生化改变和生化改变 （c）调节表皮中的细胞流量和与 Langerhans细胞。 由于其流行和相关性，特定疾病是 所研究的包括白细胞碎屑血管炎，药物喷发，荨麻疹和 特应性皮炎。 皮肤光毒反应由药物或内源性介导 光毒性化学物质（预言）为研究组织提供了出色的模型 补体系统激活和随后的损害 化学介质的释放。 Langerhans是否细胞的问题 将研究具有淋巴样细胞的“营养”功能。 它是 在体内的角色将通过评估其参与多种 细胞介导的免疫机制的皮肤疾病似乎是 涉及。 这些研究不仅可以帮助我们进一步了解这一点 区域，但将用于开发新的治疗方法。