BACTERIAL INTERRELATIONSHIPS IN AN ANIMAL MODEL

动物模型中的细菌相互关系

• 批准号: 3917231
• 负责人: STEPHEN J CHALLACOMBE
• 金额: --
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3917231
• 关键词: Actinomyces; Lactobacillus casei; Streptococcus mutans; bacteria; dental caries; disease /disorder model; enzyme linked immunosorbent assay; germ free condition; laboratory rat; oral bacteria; physical chemical interaction

1) To study bacterial interrelationships in an in vivo gnotobiotic animal model of the bacteria Streptococcus mutans, Lactobacillus casei and Actinomyces viscosus. 2) To determine the effects of sequential inoculation of the colonization of bacteria and subsequent production of caries. 3) To determine the effect on the production of caries of mono- and of multiple inoculation. 4) To determine the effects of modulation of the host response to one or more of the bacteria on the colonization and production of caries. 5) To compare the results obtained in the in vivo model with those obtained in the in vitro experiment (Clarkson, R01 Root caries study in vitro).

1）在体内gnotobiotic中研究细菌相互关系 细菌的动物模型链球菌突变，乳杆菌 酪蛋白和放线菌。 2）确定顺序接种的影响 细菌的定殖和随后的龋齿产生。 3）确定对单声道龋齿产生的影响 和多次接种。 4）确定主机响应对 关于定植和生产的一种或多种细菌 龋齿。 5）将体内模型中获得的结果与 在体外实验中获得的那些（克拉克森，R01根 龋齿在体外研究）。