CHILDRENS CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3557019
• 负责人: GERALD S GILCHRIST
• 金额: $ 16.42万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-01-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3557019
• 关键词: 6 thiopurine; Epstein Barr virus; Ewing's tumor; Hodgkin's disease; acute leukemia; antibody formation; antineoplastics; asparaginase; bone neoplasms; brain neoplasms; cancer pain; cancer rehabilitation mental health service; carmustine; combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytogenetics; drug adverse effect; drug metabolism; glioma; human subject; human therapy evaluation; methyltransferase; neoplasm /cancer chemotherapy; neoplasm /cancer epidemiology; neoplasm /cancer immunology; neoplasm /cancer radiation therapy; neoplasm /cancer radiodiagnosis; neoplasm /cancer surgery; nephroblastoma; osteosarcoma; pediatric neoplasm /cancer; radionuclide imaging /scanning; thiopurine

The primary objective of this proposal is to continue to support and expand Mayo Clinic's participation in the activities of Childrens Cancer Study Group through: 1.) Evaluating new cancer Chemotherapeutic Agents, and developing new approaches to treatment of children with cancer by, a) maintaining a leadership role in CCSG phase II an New Agent Study Committees, b) performing pilot studies for potential incorporation into future randomized CCSG trials, c) entering patients on new agent studies as exemplified by approximately 40 such patient entries during 1987, d) utilizing the resources in Doctor Ames' pharmacology laboratory to evaluate the pharmacology an pharmacokinetics of cancer chemotherapy. 2.) Improving treatment and potential for cure of various childhood cancers and leukemias by, a) continuing to enter patients into CCSG treatment protocols (90+ patients per year) with the expectation that study entries will increase as new studies for various tumor systems are activated, b) playing a leadership role in CCSG study committees (5 chairmen), d) studying long-term effects of treatment. 3.) Studying the biology and epidemiology of childhood cancer by a) membership on the Cancer Biology Committee, b) making available to CCSG the skills and resources of CCSG investigators in Pathology, Immunology, Cytogenetics and other areas of basic and applied laboratory research. 4.) Improving supportive care of children with cancer by, a) continued participation in CCSG supportive care studies, b) standardization of drug administration procedures for various chemotherapeutic agents, c) development and evaluation of methods for measuring and controlling cancer-related and procedure-related pain. 5.) Providing access for patients in outlying areas to these clinical research programs through affiliates in Des Moines, Iowa; Fargo, North Dakota; Duluth, Minnesota; Saskatoon, Saskatchewan; and Sioux Fall, South Dakota.

该提案的主要目的是继续支持 并扩大梅奥诊所参与活动 通过以下方式，儿童癌症研究小组： 1.）评估新的癌症化学治疗剂并发展 通过a的新方法治疗癌症儿童 在CCSG II阶段保持领导角色 委员会b）进行潜在融合的试点研究 进入未来的随机CCSG试验，c）进入新的患者 大约40名此类患者的代理研究例证 1987年期间的条目，d）利用埃姆斯医生的资源 药理学实验室评估药理学 癌症化疗的药代动力学。 2.）改善治疗和治愈各种童年的潜力 通过a）继续将患者纳入CCSG的癌症和白血病 预期的治疗方案（每年90多名患者） 随着各种肿瘤的新研究，该研究条目将增加 激活系统，b）在CCSG研究中发挥领导作用 委员会（5名主席），d）研究的长期影响 治疗。 3.）研究儿童癌症的生物学和流行病学 a）癌症生物学委员会的会员资格，b）提供 CCSG CCSG调查人员的技能和资源 病理学，免疫学，细胞遗传学以及其他基本和其他领域 应用实验室研究。 4.）改善对癌症儿童的支持性护理，a） 继续参与CCSG支持护理研究，b） 药物管理程序的标准化 化学治疗剂，c）方法的开发和评估 用于测量和控制与癌症有关的和程序有关的 疼痛。 5.）为这些地区的患者提供访问权限 爱荷华州得梅因市的分支机构临床研究计划； 法戈，北达科他州；明尼苏达州德卢斯；萨斯卡通，萨斯喀彻温省； 和南达科他州的苏福尔。