CHILDRENS CANCER GROUP

儿童癌症组

• 批准号: 2607996
• 负责人: GERALD S GILCHRIST
• 金额: $ 15.9万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-01-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2607996
• 关键词: Ewing's tumor; Hodgkin's disease; Wilms' tumor; brain neoplasms; child (0-11); clinical trials; combination cancer therapy; combination chemotherapy; cooperative study; germ cell neoplasms; histiocytosis X; human subject; human therapy evaluation; leukemia; liver neoplasms; neoplasm /cancer chemotherapy; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; neuroblastoma; nonHodgkin's lymphoma; osteosarcoma; pediatric neoplasm /cancer; retinoblastoma; rhabdomyosarcoma

The primary objective of this proposal is to continue to support and expand Mayo Clinic's participation in the activities of Childrens Cancer Group through: 1.) Evaluating new cancer chemotherapeutic agents and developing new approaches to treatment of children with cancer by, a) maintaining a leadership role in CCG Phase II and New Agent Study Committees, b) performing pilot studies for potential incorporation into future randomized CCG trials, c) entering patients on new agent studies, d) utilizing the resources in Doctor Ames' pharmacology laboratory to evaluate the pharmacology and pharmacokinetics of cancer chemotherapy. 2.) Improving treatment and potential for cure of various childhood cancers and leukemias by, a) continuing to enter patients into CCG treatment protocols with the expectation that study entries will increase as new studies for various tumor systems are activated, b) playing a leadership role in CCG Strategy Groups in order to develop new approaches to the treatment of childhood cancer, c) participating in the development of new randomized trials for the treatment of specific diseases and maintaining active participation in CCG study committees by Mayo investigators currently assigned to study committees d) studying long-term effects of treatment. 3.) Studying the biology and epidemiology of childhood cancer by, a) active participation in regional and CCG case-control epidemiology studies, b) making available to CCG the skills and resources of Mayo investigators in Pathology, Immunology, Molecular Biology, Cytogenetics and other areas of basic and applied laboratory research. 4.) Improving supportive care of children with cancer by, a) continued participation in CCG supportive care studies, b) standardization of drug administration procedures for various chemotherapeutic agents, c) development and evaluation of methods for measuring and controlling cancer-related and procedure-related pain. 5.) Providing access for patients in outlying areas to these clinical research programs through affiliates in Des Moines, Iowa; Fargo, North Dakota; Duluth, Minnesota; Regina and Saskatoon, Saskatchewan; and Sioux Falls, South Dakota.

该提案的主要目的是继续支持和 扩大梅奥诊所参与儿童癌的活动 小组通过： 1.）评估新的癌症化学治疗剂并开发新的 通过a）维护a）治疗癌症儿童的方法 CCG II期和新代理研究委员会的领导角色，b） 进行试点研究，以将潜在纳入未来 随机CCG试验，c）进入新药物研究的患者，d） 利用Ames医生的药理学实验室中的资源 评估癌症化学疗法的药理学和药代动力学。 2.）改善治疗和治愈各种童年的潜力 癌症和白血病，a）继续将患者输入CCG 期望研究条目会增加的治疗方案 由于激活了各种肿瘤系统的新研究，b）玩 在CCG战略小组中的领导角色，以开发新方法 治疗儿童癌症，c）参与发展 用于治疗特定疾病的新随机试验和 维持Mayo的CCG研究委员会积极参与 目前分配给研究委员会的调查人员d）研究长期 治疗的影响。 3.）研究儿童癌症的生物学和流行病学，a） 积极参与区域和CCG病例对照流行病学 研究，b）可用于CCG蛋黄酱的技能和资源 病理学，免疫学，分子生物学，细胞遗传学研究者 以及基本和应用实验室研究的其他领域。 4.）改善对癌症儿童的支持性护理，a）继续 参与CCG支持护理研究，b）药物的标准化 各种化学治疗剂的管理程序，c） 制定和评估测量和控制的方法 与癌症相关的疼痛。 5.）为这些临床的偏远地区的患者提供访问权限 爱荷华州得梅因市的分支机构研究计划；法戈，北 达科他州；明尼苏达州德卢斯；萨斯喀彻温省的里贾纳和萨斯卡通；和苏 南达科他州瀑布。