CHILDREN'S CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3557014
• 负责人: GERALD S GILCHRIST
• 金额: $ 11.64万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-01-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3557014
• 关键词: 6 thiopurine; Epstein Barr virus; Hodgkin's disease; antibody formation; asparaginase; bone neoplasms; brain neoplasms; cancer rehabilitation mental health service; carmustine; combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; drug adverse effect; glioma; human subject; human therapy evaluation; nasopharyngeal neoplasms; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer radiodiagnosis; neoplasm /cancer surgery; osteosarcoma; pediatric neoplasm /cancer; sarcoma; testis neoplasms; thiopurine

The primary objective of the proposal is to support Mayo Clinic's participation in the Children's Cancer Study Group. This will allow continuing support for the cooperative group activites of the Pediatric Oncology Group at Mayo Clinic and its satellites in Des Moines, Iowa; Fargo, North Dakota; and Duluth, Minnesota. The ultimate goal of the proposal is to develop methods for long-term control and cure in a wide variety of malignant diseases in children while evaluating and minimizing the adverse short-term and long-term effects of treatment. Clinical research in pediatric cancer demands a coordinated team effort involving surgeons, therapeutic radiologists, pathologists, pediatric oncologists, immunologists, histochemists, pharamcologists and radiologists. Solid tumor treatment protocols are becoming increasing more complex and accurate pretreatment staging and standardized operative, radiotherapuetic and chemotherapeutic procedures are essential. Since pediatric surgeons, pediatric urologists, orthopedic oncologic surgeons and diagnostic radiologists play a major role in diagnosis, staging and surgical therapy of solid tumor patients and also participate actively in postoperative evaluation, reporting and data analysis, their formal involvement in this program is critical for maintaining the highest level of clinical and laboratory research within the Children's Cancer Study Group. In addition, psychosocial evaluation and support for the patient and family is considered essential to the successful outcome of this type of clinical research and can also provide a basis for the development of clinical research studies for evaluating the psychosocial impact of cancer on children and their families.

该提案的主要目的是支持梅奥诊所的参与 在儿童癌症研究小组中。 这将允许继续支持 梅奥诊所的小儿肿瘤学组的合作小组活动 及其在爱荷华州得梅因市的卫星；法戈，北达科他州；和Duluth， 明尼苏达州。 该提案的最终目标是开发长期控制的方法 并在评估儿童的各种恶性疾病中治愈 并最大程度地减少治疗的短期和长期影响。 小儿癌的临床研究需要协调的团队努力 涉及外科医生，治疗放射学家，病理学家，小儿 肿瘤学家，免疫学家，组织化学家，吞噬学家和放射科医生。 实体瘤治疗方案变得越来越复杂，并且 准确的预处理分期和标准化手术剂，放射治疗和 化学治疗程序至关重要。 由于小儿外科医生，小儿 泌尿科医生，骨科肿瘤外科医师和诊断放射科医生扮演 实体瘤患者的诊断，分期和手术治疗中的主要作用 并积极参与术后评估，报告和数据 分析，他们的正式参与该计划对于维护至关重要 儿童中最高水平的临床和实验室研究 癌症研究组。 此外，社会心理评估和对 病人和家庭被认为是成功结果至关重要的 临床研究的类型，也可以为发展提供基础 评估癌症的心理社会影响对临床研究 儿童及其家人。