MULTIPLE SCLEROSIS--A PROGRAM PROJECT

多发性硬化症——一个计划项目

• 批准号: 3100149
• 负责人: BARRY G ARNASON
• 金额: $ 105.45万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1996-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3100149
• 关键词: multiple sclerosis

This program project deals with myelination, demyelination, and remyelination as it pertains to multiple sclerosis (MS). Project 1 is concerned with immunocyte function (particularly that of T suppressor cells and monocytes) in MS and how it can be manipulated so as to favorably influence the course of the disease. Suppressor function is decreased when MS is active, whereas monocyte function is increased. Emphasis is placed on beta2-adrenergic and muscarinic cholinergic receptors on lymphocytes and monocytes and their role in cell function. Both classes of receptor are up-regulated on immunocytes in progressive MS. Project 2 deals with proteoglycans and glycoproteins synthesized by oligodendrocyte known as OMgp which has been cloned and sequenced. The function of OMgp remains to be determined and is a major goal of Project 3. There is reason to believe, based on its structure, that OMgp will prove to be an adhesion molecule. Project 4 is directed towards Theiler's virus-induced demyelination as a model for the demyelination that characterized MS. The goal is to establish the determinants on Theiler's virus responsible for demyelination using molecular biologic techniques. The entire genome of three strains of Theiler's virus has been sequenced which should facilitate this task. Project 6 is directed to a study of the effects of cytokines on ion channels in sympathetic neurons. There are extensive interactions between the various projects and the two cores - Core A administrative and Core B scientific. The latter provides patient and control samples to the various projects.

该计划项目涉及髓鞘化，脱髓鞘和 与多发性硬化症有关（MS）的透明度。 项目1是 与免疫细胞功能有关（尤其是T抑制细胞的功能 MS中的单核细胞）以及如何对其进行操作，以使其有利 影响疾病的过程。 当抑制器功能降低时 MS是活跃的，而单核细胞功能则增加。 重点是放置 在beta2-肾上腺素能和毒蕈碱胆碱能受体上，淋巴细胞和 单核细胞及其在细胞功能中的作用。 两类受体都是 在进行性MS中的免疫细胞上上调。 项目2处理 由少突胶质细胞合成的蛋白聚糖和糖蛋白被称为 OMGP已被克隆和测序。 OMGP的功能仍然 确定并是项目3的主要目标。有理由 相信，基于其结构，OMGP将被证明是一种粘附 分子。 项目4针对Theiler的病毒诱导 脱髓鞘是特征MS的脱髓鞘模型。 这 目标是建立负责Theiler病毒的决定因素 使用分子生物学技术脱髓鞘。 整个基因组 已经对Theiler病毒的三种菌株进行了测序，这应该有助于 这个任务。 项目6针对细胞因子对 交感神经元中的离子通道。 有广泛的互动 在各个项目和两个核心之间 - 核心管理和 核心科学。 后者为患者提供并控制样本 各种项目。