Autoantibodies and antibody-secreting cells in neurological autoimmune diseases: from biology to therapy

神经性自身免疫性疾病中的自身抗体和抗体分泌细胞：从生物学到治疗

• 批准号: 479128
• 负责人: Vallières Luc
• 金额: $ 82.9万
• 依托单位: CHU de Qubec
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2023
• 资助国家: 加拿大
• 起止时间: 2023-03-01 至 2028-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=479128&lang=en
• 关键词: Anti-Mog Antibodies; Autoantibodies; Cns Autoimmunity; Demyelinating Autoimmune Diseases; Experimental Autoimmune Encephalomyelitis (Eae); Mog Antibody Disease (Mogad); Multiple Sclerosis; Neuroimmunology; Neuroinflammation; Plasmablasts; Anti-Mog Antibodies; Autoantibodies; Cns Autoimmunity; Demyelinating Autoimmune Diseases; Experimental Autoimmune Encephalomyelitis (Eae); Mog Antibody Disease (Mogad); Multiple Sclerosis; Neuroimmunology; Neuroinflammation; Plasmablasts

Demyelinating autoimmune diseases, such as multiple sclerosis (MS), result from dysfunctions of the immune system that cause it to destroy myelin in the nervous system. As B cells (a type of immune cells) play key roles in these diseases, B cell-depleting

由免疫系统功能障碍引起的自身免疫性疾病（例如多发性硬化症（MS））导致其在神经系统中破坏髓磷脂。随着B细胞（一种免疫细胞）在这些疾病中起关键作用，B细胞消耗