NEUROPHYSIOLOGICAL ABNORMALITIES--SENSORY GATING PHENOTYPES

神经生理异常——感觉门控表型

• 批准号: 3781940
• 负责人: ROBERT FREEDMAN
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3781940
• 关键词: auditory feedback; auditory pathways; auditory stimulus; disease /disorder proneness /risk; electroencephalography; evoked potentials; eye movement disorders; gene expression; genetic disorder; genetic mapping; human genetic material tag; human subject; mental health epidemiology; neural information processing; neural transmission; neurobiology; nucleic acid repetitive sequence; perception disorder; schizophrenia; sensory mechanism; smooth pursuit eye movement

Two neurophysiological abnormalities, a deficit in the gating of the auditory evoked potential wave P50 in the conditioning- testing paradigm and a deficit in smooth pursuit eye movements (SPEM), are frequently found in both schizophrenics and in their relatives. The principal aim of this Project, in conjunction with Project 2, is to determine if these two neurophysiological abnormalities represent phenotypic expressions of the gene or genes which convey risk for schizophrenia. Multigenerational families including schizophrenic probands, recruited in Utah, will be evaluated for both abnormalities. The neurophysiological phenotypes will then be genotyped using complementary DNA techniques, to determine if either or both measures can be linked to specific genetic loci. Deficits in P50 gating and SPEM are both thought to be examples of the problems in sensory gating which seem to underlie the psychopathology of schizophrenia. However, a comprehensive understanding of the neurobiology of sensory gating has not yet been achieved. The goal of Project 3 is to describe the neurobiology of P50 gating in laboratory animal models. As better descriptions of the neurobiology are obtained, Project 1 will determine if better measures of sensory gating can be added to the P50 gating and SPEM measurements in current use. Our overall goal in Project 1 is to demonstrate as precisely as possible the phenotypic expression of the gene of genes which convey genetic risk for schizophrenia.

两个神经生理异常，门控的赤字 听觉诱发了调节中的电势P50 测试范式和光滑追捕眼动的赤字 （SPEM）在精神分裂症患者及其中经常发现 亲属。 该项目的主要目的，结合 使用项目2，是确定这两个神经生理学是否 异常代表基因或 传达精神分裂风险的基因。 多代 在犹他州招募的精神分裂症可能性的家庭， 将评估两种异常。 神经生理学 然后，将使用互补DNA对表型进行基因分型 技术，确定是否可以链接任何一种或两种措施 到特定的遗传基因座。 P50门控和SPEM的缺陷是 两者都被认为是感觉门控问题的例子 这似乎是精神分裂症的心理病理学的基础。 但是，对神经生物学的全面理解 感官彩控尚未实现。 项目3的目标 是描述实验室P50门控的神经生物学 动物模型。 因为神经生物学的更好描述是 获得的，项目1将确定是否更好地衡量感觉 可以将门控添加到P50门控和SPEM测量中 当前使用。 我们在项目1中的总体目标是证明 精确地表型表达的基因的表型表达 传达精神分裂症遗传风险的基因。