CLINICAL STUDIES OF SENSORY GATING

感觉门控的临床研究

• 批准号: 3759832
• 负责人: ROBERT FREEDMAN
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3759832
• 关键词: attention; auditory stimulus; brain electrical activity; disease /disorder proneness /risk; electroencephalography; electrooculography; evoked potentials; eye movement disorders; family genetics; genetic disorder; human fetus tissue; human genetic material tag; human subject; linkage mapping; mental disorder diagnosis; neurotransmitter metabolism; nicotine; norepinephrine; perception disorder; phenotype; postmortem; schizophrenia; sensory feedback; sensory mechanism; smooth pursuit eye movement

Project 1 is responsible for clinical studies of physiological phenotypes related to schizophrenia. The aim of Centers for Neuroscience of Mental Disorders is to bring basic science expertise to bear upon chronic mental disorder. However, these disorders are complex, multi-faceted syndromes that are not immediately amenable to basic science investigation. This project is responsible for identifying discrete deficits in schizophrenics that may more directly represent neuronal dysfunction, so that other projects can use these deficits for genetic and molecular studies, for study in isolated tissue, and for modeling in animals. Project 1 is also responsible for testing in human subjects any hypotheses reached from basic science research. Two physiological measures will be used for most studies: deficits in smooth pursuit eye movements and diminished inhibitory gating of the P50 auditory evoked potential response. Three experiments will be performed: (1) linkage studies using these measures in collaboration with Project 2, along with clinical diagnoses, to determine if one or more of these phenotypes identifies genes relevant to the transmission of schizophrenia; (2) studies of the effects of nicotine on the measures, to determine if nicotine normalizes the defects, as predicted by Project 3's animal model; and (3) investigations to define factors, such as increased catecholamine metabolism, that cause variability in these measures, to improve their usefulness for clinical research. In addition, Project 1 collects post mortem and aborted tissue specimens for Projects 6 and 7.

项目1负责生理表型的临床研究 与精神分裂症有关。 心理神经科学中心的目的 疾病是为基础科学专业知识带来慢性精神 紊乱。 但是，这些疾病是复杂的多面综合症 不受基础科学调查的立即调查。 这 项目负责确定离散赤字 精神分裂症患者可能更直接代表神经元功能障碍，因此 其他项目可以将这些缺陷用于遗传和分子 研究，用于在孤立的组织中进行研究，用于动物建模。 项目1还负责在人类受试者中进行测试 基础科学研究得出的假设。 两个生理学 大多数研究将使用措施：光滑追捕眼中的缺陷 动作并减少了P50听觉的抑制性门控 潜在反应。 将进行三个实验：（1）连接 使用这些措施与项目2合作的研究以及 临床诊断，以确定其中一种或多种表型是否 鉴定与精神分裂症传播相关的基因； （2） 研究尼古丁对措施的影响，以确定是否是否 如项目3的动物所预测的那样，尼古丁将缺陷归一化 模型; （3）定义因素的调查，例如增加 儿茶酚胺代谢，导致这些措施的可变性， 提高其对临床研究的有用性。 此外，项目1 收集项目6和7的验尸和流产的组织标本。