NEUROPSYCHOLOGICAL, ANATOMICAL, AND PHYSIOLOGICAL CORRELATES OF MOOD DISORDERS

情绪障碍的神经心理学、解剖学和生理学相关性

• 批准号: 3781430
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3781430
• 关键词: brain mapping; brain metabolism; clinical depression; computed axial tomography; cortisol; epilepsy; face expression; frontal lobe /cortex; functional ability; human subject; magnetic resonance imaging; mood disorders; neuropsychological tests; neuropsychology; positron emission tomography; temporal lobe /cortex

Neuropsychological testing has revealed that affectively ill patients have impaired performance on the Halstead Category Test, and recognition of facial emotional expression in contrast with unimpaired verbal emotion recognition tasks. Patients also report lifetime disturbances in tasks and activities of daily living including visual spatial processing, but not those in the verbal mode. The neural substrates of these deficits are systematically being explored by a variety of techniques including testing patients utilizing 015 blood flow studies with PET methodology (See MH 02636-01 BP and MH 02638-01 BP). CAT scan studies have revealed increased VBR in patients with affective disorders unrelated to the course of illness, but positively related to age, measures of cortisol hypersecretion, and impairment on the Halstead Category Test. MRI studies suggest decreased area and volume of the temporal lobe in affec- tively ill subjects compared with controls. Evidence of frontal hypome- tabolism is revealed on PET scan studies in patients with primary affec- tive disorders as well as depression associated with epilepsy. Temporal and parietal alterations are also evident.

神经心理学测试表明，情绪疾病的患者 在Halstead类别测试中的性能受损，并认可 面部情绪表达与未损坏的言语情绪形成鲜明对比 识别任务。 患者还报告任务中的终身障碍 以及日常生活的活动，包括视觉空间处理，但 不是口头模式的人。 这些缺陷的神经底物 正在系统地探索各种技术 使用宠物方法学的015血流研究测试患者 （请参阅MH 02636-01 BP和MH 02638-01 bp）。 猫扫描研究表明 情感障碍患者的VBR增加与 疾病的过程，但与年龄相关，皮质醇的度量是正相关的 在Halstead类别测试中进行过度分泌和损害。 MRI 研究表明，颞叶的面积减少和体积 与对照组相比，病情病态的受试者。 额叶高hypome的证据 在主要亲戚患者的PET扫描研究中揭示了Tabolism- 与癫痫有关的疾病以及抑郁症。 颞 顶叶也很明显。