THERAPEUTIC AND MECHANISTIC EFFECTS OF SLEEP DEPRIVATION IN DEPRESSION

睡眠剥夺对抑郁症的治疗作用和机制作用

• 批准号: 3859981
• 负责人: R M POST
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859981
• 关键词: bipolar depression depressed phase; clinical depression; hormone regulation /control mechanism; human subject; metabolism; mood disorders; neurobiology; sleep deprivation; thyrotropin

One night's total sleep deprivation can induce profound antidepressant effects in depressed patients. Following the absence of sleep for one night, 40-60% of depressed patients typically show the transient onset of mood improvement which is then lost following a nap or the next night's recovery sleep. Thus, the sleep deprivation paradigm becomes a non- pharmacological means of acutely inducing altered mood states in a fashion that may yield important information about underlying mechanisms. While the mood changes are usually transient they may, nonetheless, give insights into neural systems involved in mood dysregulation and its acute reversal. Some patients show stable degrees of improvement following sleep deprivations, while others show tolerance and yet others show a relative refractoriness to sleep deprivation-induced mood improvement early in their bipolar depressive episode, but vulnerability to transient or long-lasting switches out of depression later in the course of their episode. These data provide some of the first systematic observations regarding differential neurobiological responsiveness as a function of the course of a bipolar depressive episode. Preliminary data suggest that increases in TSH secretion may be associated with the degree of clinical response to sleep deprivation in our patient population as a whole, as well as individual case studies.

一晚的完全睡眠剥夺会引起深刻的抗抑郁药 在抑郁症患者中的影响。 在没有睡眠之后 晚上，40-60％的抑郁症患者通常显示 情绪改善，然后在午睡或第二天晚上失去 恢复睡眠。 因此，睡眠剥夺范式变成了非 急性诱导情绪状况改变的药理方法 这可能会产生有关潜在机制的重要信息。 尽管 心情变化通常是短暂的，尽管如此，它们仍然可以提供见解 进入涉及情绪失调及其急性逆转的神经系统。 一些患者在睡眠后显示出稳定的改善程度 剥夺，而其他人则表现出宽容，而其他人则表现出亲戚 耐睡眠剥夺引起的情绪改善的早期 双极性抑郁发作，但易受瞬态或持久的脆弱性 在剧集的过程中，切换出抑郁症。 这些 数据提供了一些有关的第一个系统观察 差异神经生物学反应性随着过程的函数 双极抑郁发作。 初步数据表明增加 TSH分泌可能与对 整个患者人群的睡眠剥夺以及 个别案例研究。