THIOL CONTAINING LIGANDS FOR PB(II) AND BI(III)

PB(II) 和 BI(III) 的含硫醇配体

• 批准号: 3774585
• 负责人: M W BRECHBIEL
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774585
• 关键词: bismuth; chelating agents; chemical synthesis; immunoconjugates; lead; ligands; metal complex; sulfur; thiols

The goal of the project is to synthesize bifunctional ligands which have a high affinity for Pb(II) and Bi(III) by virtue of the presence of sulfur donor atoms. Simple thiolate ligands such as dimercaptosuccinic acid have been shown to form complexes of high stability with both ions (Kf for the 1:2 BiDMSA complex in log 43.87), yet appropriate multidentate chelating agents suitable for linkage to monoclonal antibodies are not yet available. As such, systematic exploration of the chemistry of incorporating thiol donor groups into both existing and new acylic and cyclic chelating agents is planned. Appropriate precursor molecules will be synthesized to allow testing of the methodology for the incorporation of thiols into new chelating agents for protein modification.

该项目的目标是合成双功能配体，其具有 由于存在，对 Pb(II) 和 Bi(III) 具有高亲和力 硫供体原子。 简单的硫醇配体，例如二巯基琥珀酸 酸已被证明可以与两种离子形成高稳定性的络合物 （Kf 为 log 43.87 中 1:2 BiDMSA 复合物），但合适 适合连接单克隆抗体的多齿螯合剂 目前还没有抗体。 因此，系统地探索 将硫醇供体基团纳入现有和新的化学 计划使用无酰基和环状螯合剂。 适当的前体 将合成分子以允许测试方法 将硫醇掺入新的蛋白质螯合剂中 修改。