BIFUNCTIONAL CHELATING AGENTS FOR GALLIUM (III)

镓 (III) 双功能螯合剂

• 批准号: 5201262
• 负责人: M W BRECHBIEL
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201262
• 关键词: chelating agents; chemical binding; chemical stability; chemical synthesis; gallium; immunoconjugates; ligands; radiochemistry; radionuclides; radiopharmacology

The synthesis and evaluation of bifunctional chelating agents designed to sequester Ga (III) isotopes define the general scope of the project. Taking advantage of extensive chemical literature elucidating the coordination chemistry of Ga(III) investigation into a new class of hexadentate ligands has been initiated. These chelating agents are based on the cis,cis-1,3,5-triaminocyclohexane system which then functions as a platform for introduction of a wide variety of metal binding functional groups. Two new chelating agents have been synthesized and characterized and have been found to form metal complexes with a variety of metal ions. The tris(pyridyl) triamine derivative has been shown to form a gallium complex of potentially useful stability justifying further in vivo evaluation.

双功能螯合剂的合成与评价 螯合 Ga (III) 同位素定义了该项目的一般范围。 利用大量化学文献阐明 Ga(III)配位化学研究一类新的 六齿配体已经启动。 这些螯合剂基于 在 cis,cis-1,3,5-三氨基环己烷系统上，然后充当 引入各种金属结合功能的平台 组。 两种新型螯合剂的合成和表征 并已被发现能与多种金属离子形成金属络合物。 三(吡啶基)三胺衍生物已被证明可以形成镓 潜在有用的稳定性复合物在体内进一步证明合理 评估。