THIOL CONTAINING LIGANDS FOR PB(II) AND BI(III)

PB(II) 和 BI(III) 的含硫醇配体

• 批准号: 3838070
• 负责人: T J MCMURRY
• 金额: --
• 依托单位: DIVISION OF CANCER TREATMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838070
• 关键词: bismuth; chelating agents; chemical synthesis; immunoconjugates; lead; ligands; thiols

The goal of the project is to synthesize bifunctional ligands which have a high affinity for Pb(II) and Bi(III) by virtue of the presence of sulfur donor atoms. Simple thiolate ligands such as dimercaptosuccinic acid have been shown to form complexes of high stability with both ions (Kf for the 1:2 Bi:DMSA complex is log 43.87), yet appropriate multidentate chelating agents suitable for linkage to monoclonal antibody are not yet available. We intend to systematically explore this chemistry by incorporating thiol donor atoms into both acyclic and cyclic chelating agents. Appropriate precursor molecules have been synthesized which will allow us to test methodology for the incorporation of thiols into new chelating agents.

该项目的目标是合成双功能配体，其具有 由于存在，对 Pb(II) 和 Bi(III) 具有高亲和力 硫供体原子。 简单的硫醇配体，例如二巯基琥珀酸 酸已被证明可以与两种离子形成高稳定性的络合物 （1:2 Bi:DMSA 复合物的 Kf 为 log 43.87），但合适 适合连接单克隆抗体的多齿螯合剂 尚不可用。 我们打算系统地探讨这个问题 通过将硫醇供体原子掺入无环和环状化学中 螯合剂。 已经合成了合适的前体分子 这将使我们能够测试硫醇掺入的方法 成为新的螯合剂。