BREEDING & EXPERIMENTAL FACILITY

配种

• 批准号: 2295819
• 负责人: BUD C TENNANT
• 金额: $ 56.4万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-16 至 1998-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2295819
• 关键词: BREEDING; EXPERIMENTAL; FACILITY; BREEDING; EXPERIMENTAL; FACILITY

The contract at Cornell University has an excellent track record in the breeding and housing of the woodchuck animal model with great lengths taken to study all aspects of this model's infection by the woodchuck hepatitis virus (WHV). This woodchuck/WHV model closely parallels the disease progression produced in humans by the hepatitis B virus (HBV). Predictable numbers of infected pups are produced yearly for experiments such as: (1) the testing of natural and synthetic antivirals and immunomodulators against WHV in infected animals, (2) the study of the coinfection/superinfection of human hepatitis delta virus (HDV) and WHV for the development of HDV vaccines and antivirals, (3) the comparison of disease progression between WHV and the related ground squirrel hepatitis virus (GSHV) in the woodchuck -- the latter producing more cirrhosis and a slower progression to hepatocellular carcinoma, (4) the study of immunologic mechanisms triggered during the acute and chronic stages of the disease and detection of possible pathways to target for prevention of chronicity, and (5) the transfection of woodchuck livers by recombinant WHV DNA to pinpoint biologically important sequences. This contract's goals are to assist with the overall efforts of the Hepatitis Program in the prevention of Types B and D viral hepatitis. Even though safe and effective vaccines are presently available for HBV, there are still over a million chronic carriers of hepatitis B in the U.S. alone. Specifically there is the potential for the eradication of long term complications such as chronic hepatitis B and D liver disease and primary hepatocellular carcinoma by immunization, immunologic methods, or therapeutic treatments.

康奈尔大学的合同在 长度很长的伍德克动物模型的繁殖和住房 用木屑研究该模型感染的所有方面 肝炎病毒（WHV）。 这种木制/WHV模型与 丙型肝炎病毒（HBV）在人类中产生的疾病进展。 可预测的被感染幼崽每年生产用于实验 例如：（1）自然和合成抗病人的测试以及 在感染动物中针对WHV的免疫调节剂，（2）研究 人类肝炎三角病毒（HDV）和WHV的共感染/超级感染 为了开发HDV疫苗和抗病毒药，（3）比较 WHV与相关地松鼠之间的疾病进展 Woodchuck中的肝炎病毒（GSHV） - 后者产生更多 肝硬化和向肝细胞癌较慢的进展，（4） 急性和慢性期间触发的免疫机制的研究 疾病的阶段以及检测可能的靶向途径 预防慢性，（5）木屋肝的转染 通过重组WHV DNA来查明对生物学上重要的序列。 该合同的目标是协助 预防B型和D病毒性肝炎的肝炎计划。 即使目前可用于HBV安全有效的疫苗， 在 仅美国。 具体而言，有可能消除 长期并发症，例如慢性丙型肝炎和D肝病 通过免疫，免疫学，原发性肝细胞癌 方法或治疗性治疗。