ALZHEIMER DISEASE CENTER

阿尔茨海默病中心

• 批准号: 2050004
• 负责人: EARL ZIMMERMAN
• 金额: $ 78.66万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-07-06 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2050004
• 关键词: Alzheimer's disease; biomedical facility

The overall mission of the Oregon Alzheimer Disease Center (OADC) is to facilitate and advance research in Alzheimer disease (AD) and related dementias. This will be achieved by maintaining 6 Core facilities in association with expert Core personnel to support both current research strengths, as well as be responsive to the developing potential of new knowledge and discoveries in the field. The Center is organized and coordinated by the Administrative Core to be an efficient unit, working in concert with the research community to facilitate investigations in several major thematic areas such as studies of preclinical or incipient dementia in the very elderly, the genetics of AD, and the relationship between AD and Parkinson disease. The Clinical Core provides well-characterized, longitudinally followed research subjects of several kinds: 1) AD and related dementias; 2) Healthy elderly at high risk for developing dementia, emphasing those older than 85 years of age; 3) Parkinson dementias; and 4) Subjects reflecting social and racial diversity (African American, Native American, and isolated rural populations) in the context of gender differences. The Clinical Core and its subject resources are linked to the Neuropathology Core through programs designed to enhance tissue donation. The Neuropathology Core uses state-of-the-art biochemical, histopathologic and morphometric techniques to characterize donated tissues which in turn are utilized by a diverse array of basic and molecular scientists both locally and nationally. The Genetics Core responds to the needs of both Clinical and Neuropathology Cores and their missions of sophisticated characterization of research subjects and tissues by family history and genotype. The Genetics Core is also responsive to basic scientists in its potential ability to facilitate study of candidate genes causing AD or genes which are protective and promote successful aging. Linking all these units is the Data Management Core which maintains an efficient relational database containing a unique catalogue record system which allows easy revision and modification of protocols as is inevitable in any longitudinal program. The Data Management Core further provides important assistance and advice in design and statistical analysis to investigators beginning to develop new projects. Finally, the information and knowledge of the field is disseminated through the Education and Information Transfer Core. This Core provides regular educational forums of many types ranging from small seminars and lectures to interactive television broadcasts. New research is encouraged by the pilot project program. Four pilot projects are proposed for year 06 addressing the following topics: 1) estrogen and trk receptors in non- human primates; 2) gender differences in cognition and AD; glucose transporter deficit in AD; and 4) somatostatin's role in neurodegeneration through a gene "knock-out" mouse model.

俄勒冈州阿尔茨海默氏病中心（OADC）的整体任务是 促进和预先研究阿尔茨海默氏病（AD）及相关的研究 痴呆症。这将通过维护6个核心设施来实现 与专家核心人员的关联以支持两项当前的研究 优势，并对新的发展潜力做出反应 领域的知识和发现。中心是组织的， 由行政核心协调为有效的单位 与研究界的音乐会，以促进一些调查 主要主题领域，例如临床前或起步性痴呆的研究 在老年人中，AD的遗传学以及AD之间的关系 和帕金森病。临床核心提供良好的特征， 纵向遵循几种研究主题：1）AD和 相关痴呆症； 2）健康的老年人有高风险发展 痴呆症，强调85岁以上的人； 3）帕金森 痴呆症； 4）反映社会和种族多样性的主题（非洲人 美国，美洲原住民和孤立的农村人口） 性别差异。临床核心及其主题资源是 通过旨在增强的计划与神经病理学核心联系 组织捐赠。神经病理学核心使用最先进的 生化，组织病理学和形态计量学技术的表征 捐赠的组织又被各种基本阵列和 分子科学家在本地和全国范围内。遗传学核心 响应临床和神经病理学核心的需求及其 研究主题和组织的复杂表征的任务 根据家族史和基因型。遗传学核心也对 基础科学家具有促进候选人研究的潜在能力 引起广告或具有保护性并促进成功的基因的基因 老化。链接所有这些单元的是数据管理核心 一个有效的关系数据库，该数据库包含独特的目录记录 系统可以轻松修改和修改协议 任何纵向计划都不可避免。数据管理核心进一步 在设计和统计分析中提供重要的帮助和建议 向调查人员开始开发新项目。最后， 该领域的信息和知识通过 教育和信息转移核心。这个核心提供了常规 许多类型的教育论坛，包括小型研讨会和讲座 进行互动电视广播。鼓励 试点项目计划。提出了第06年的四个试点项目 解决以下主题：1）非 - 雌激素和TRK受体 人类灵长类动物； 2）认知和广告中的性别差异；葡萄糖 AD中的运输赤字； 4）生长抑素在神经变性中的作用 通过基因“敲除”小鼠模型。