POPULATION GENETICS OF NATIVE AMERICAN TRIBES

美洲原住民部落的人口遗传学

• 批准号: 5200214
• 负责人: J LONG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5200214
• 关键词: Native Americans; alleles; culture; gene duplication; gene frequency; human genetic material tag; human population genetics; human subject; human tissue; language; linkage mapping

The numbers of alleles, allele frequencies, and allele frequency differences among Native American tribes will be ascertained for the short tandem repeat (STR) loci that are being employed in our linkage analyses. Approximately 30 individuals from each of 20 tribes collected primarily at the Albuquerque Indian Hospital will be analyzed. Tests for allele frequency differences between tribal groupings based on cultural and linguistic affinities will be performed. This information is important to genetic linkage and disease association studies on Native Americans because poor estimates of allele frequencies can result in false evidence for linkage, and allelic heterogeneity among groups can create spurious associations with disease.

等位基因，等位基因频率和等位基因频率的数量 将确定美国原住民部落之间的差异 短的串联重复（str）基因座在我们的链接中使用 分析。 收集的20个部落中每个部落中约有30个人 将主要在阿尔伯克基印度医院进行分析。 测试 基于文化的部落分组之间的等位基因频率差异 并将执行语言亲和力。 此信息是 对天然的遗传联系和疾病关联研究很重要 美国人，因为对等位基因频率的估计差会导致 虚假的链接证据和组之间的等位基因异质性可以 与疾病建立虚假的联系。