Dispersion and Dissolution of Hydrocolloids

亲水胶体的分散和溶解

• 批准号: EP/W029065/1
• 负责人: Michael Adams
• 金额: $ 70.26万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW029065%2F1
• 关键词: Dispersion; Dissolution; Hydrocolloids; Dispersion; Dissolution; Hydrocolloids

Hydrocolloids such as starch, carboxymethyl cellulose, guar gum, pectin and carrageenan have many industrial applications including textile and carpet printing, paper production, foods, personal care, home care, pharmaceutical and biomedical products. They are widely used for modifying the rheology and texture of formulations, stabilising microstructures and enhancing organoleptic properties and are increasingly being investigated as agents in delivery systems for high value and high functional applications, such as encapsulation and controlled release in pharmaceutical, nutraceutical, food, animal feed, agrochemical, household care and cosmetics industries. Invariably, they have to be mixed with water in order to allow swelling/dissolution to occur. However, the surfaces of the granules or encapsulates become sticky when in contact with water and this can often lead to aggregation that prevents complete swelling/dissolution. The aim of the current proposal is to develop generic numerical models that will be able to identify the optimal dispersion conditions. The interaction of water with HCs is extremely complex with the rapid formation of an outer gel layer, which causes aggregation that inhibits internal capillary flow of water into the pores so that swelling/dissolution has to rely on the much slower process of diffusion. In order to determine the optimal mixing conditions, the project will model these processes from the molecular to the industrial scale. This so-called multiphysics multiscale strategy will involve molecular dynamics, finite element analysis, discrete element modelling coupled with computational fluid dynamics and population balance modelling. It will include an experimental programme to measure the physical and mechanical properties of the hydrocolloids and also mixing measurements to validate the modelling.

诸如淀粉，羧甲基纤维素，瓜尔胶，果胶和角叉菜等的水胶体具有许多工业应用，包括纺织品和地毯印刷，纸张生产，食品，个人护理，家庭护理，制药和生物医学产品。它们被广泛用于修改配方的流变学和纹理，稳定微观结构并增强有机精神的特性，并越来越多地作为用于高价值和高功能应用的输送系统中的代理，例如在药物，营养，食品，动物，农业，家庭护理和宇宙工业中的药物，营养，营养，食物，动物饲料，农业饲料，农业，企业和宇宙工业中的封装和受控释放。总是必须与水混合，以使肿胀/溶解。但是，当与水接触时，颗粒或封装的表面变得粘稠，这通常会导致聚集，从而防止完全肿胀/溶解。当前建议的目的是开发将能够识别最佳分散条件的通用数值模型。水与HCS的相互作用非常复杂，外部凝胶层的快速形成会导致聚集，从而抑制水的内部毛细血管流入孔中，因此肿胀/溶解必须依赖于较慢的扩散过程。为了确定最佳混合条件，该项目将对这些过程从分子到工业规模进行建模。这种所谓的多物理多尺度策略将涉及分子动力学，有限元分析，离散元素建模以及计算流体动力学和种群平衡建模。它将包括一个实验程序，以测量氢胶体的物理和机械性能，并混合测量以验证建模。