Control of catecholamine synthesis and secretion by angiotensin II.

血管紧张素 II 控制儿茶酚胺的合成和分泌。

• 批准号: nhmrc : 209857
• 负责人: A/Pr Phillip Dickson
• 金额: $ 18.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-catecholamine-synthesis-angiotensin-ii/100612
• 关键词: Control; catecholamine; synthesis; secretion; angiotensin

In the stress response the catecholamines, including adrenaline, are secreted by the adrenal gland and the brain. This leads to the synthesis of new catecholamines in order to replace those that were lost. Synthesis of catecholamines is controlled by the activity and the amount of the enzyme tyrosine hydroxylase. Catecholamine synthesis and secretion is therefore a fundamental physiological process. This can be controlled by a number of mechanisms, including hormones such as angiotensin II. Angiotensin II has a number of functions including the control of blood pressure and body fluid homeostasis. Angiotensin II acts on the adrenal glands, the sympathetic nerves and the brain to produce these effects. It does so by increasing the secretion of catecholamines and these in turn modulate blood pressure and fluid homeostasis. The mechanism(s) whereby angiotensin II induces catecholamine secretion is not known, nor is it known how this leads to increased tyrosine hydroxylase activity and synthesis. The aim of this grant is therefore to determine how angiotensin II induces the activation of tyrosine hydroxylase, the secretion of catecholamines and the synthesis of new tyrosine hydroxylase. The significance of this work is that it will allow us to better understand how angiotensin II works and it will provide insights into the generation and control of hypertension and the mechanisms of the stress response. It is known that the pathways involved in angiotensin II stimulation of catecholamine secretion can be blocked by inhibitors of protein kinases and this leads to a reduction in blood pressure. It is therefore likely that this work will have therapeutic implications.

在应激反应中，儿茶酚胺（包括肾上腺素）由肾上腺和大脑分泌。这导致新的儿茶酚胺的合成，以取代那些丢失的儿茶酚胺。儿茶酚胺的合成由酪氨酸羟化酶的活性和数量控制。因此，儿茶酚胺的合成和分泌是一个基本的生理过程。这可以通过多种机制来控制，包括血管紧张素 II 等激素。血管紧张素 II 具有多种功能，包括控制血压和体液稳态。血管紧张素 II 作用于肾上腺、交感神经和大脑以产生这些作用。它通过增加儿茶酚胺的分泌来实现这一点，而这些反过来又调节血压和体液稳态。血管紧张素 II 诱导儿茶酚胺分泌的机制尚不清楚，也不知道这如何导致酪氨酸羟化酶活性和合成增加。因此，这项资助的目的是确定血管紧张素 II 如何诱导酪氨酸羟化酶的激活、儿茶酚胺的分泌以及新酪氨酸羟化酶的合成。这项工作的意义在于，它将让我们更好地了解血管紧张素II的工作原理，为高血压的产生和控制以及应激反应的机制提供深入的见解。众所周知，血管紧张素 II 刺激儿茶酚胺分泌的途径可以被蛋白激酶抑制剂阻断，从而导致血压降低。因此，这项工作很可能具有治疗意义。