PRECHRONIC STUDIES OF DIPHENYLGUANIDINE

二苯胍的慢性研究

• 批准号: 2311419
• 负责人: LOUIS T MULLIGAN
• 金额: $ 1.9万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-02-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2311419
• 关键词: PRECHRONIC; STUDIES; DIPHENYLGUANIDINE

1, 3 Diphenylguanidine was nominated for testing by NCI because of the potential human exposure during production and use (rubber vulcanization) and because of lack of sufficient toxicity data for the guanidine class of chemicals. The objectives of the planned prechronic (14-day & 13-week) dosed feed studies in rats and mice are: 1. To characterize the toxicity associated with the repeated exposure to the chemical, the "no-effect-level", differences in sensitivity between sexes and species and the slope of the dose response curve. 2. To select the proper doses for use in a 2-year study to be designed for determining the carcinogenic potential of this chemical. The dosed feed route of administration was selected because human exposure could occur through this route and because the chemical is readily absorbed by rodents following consumption.

1，3二苯基瓜尼丁通过NCI提名 生产和使用期间的潜在人类暴露（橡胶硫化） 而且由于缺乏足够的毒性数据 化学物质。 计划中的预测（14天和13周）的供稿的目标 在大鼠和小鼠中的研究是：1。表征相关的毒性 随着重复接触该化学物质的“无效级别”， 性别和物种之间的敏感性差异以及 剂量反应曲线。 2。选择适当的剂量以在2年内使用 设计用于确定这一点的致癌潜力的研究 化学。 选择给药的剂量途径是因为人类 暴露可能通过这条路线发生，因为化学物质是 消耗后啮齿动物很容易吸收。