MAINTAINING FUNCTIONS IN AGED COMMUNITY RESIDENTS

维护老年社区居民的功能

• 批准号: 3453649
• 负责人: Mary Sano
• 金额: $ 11.51万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3453649
• 关键词: clinical trials; cognition disorders; dementia; deprenyl; disease /disorder prevention /control; disease /disorder proneness /risk; functional ability; human old age (65+); human subject; human therapy evaluation; longitudinal human study; mental disorder chemotherapy; mental disorder diagnosis; neuropsychological tests; pathologic process; prognosis; quality of life

DESCRIPTION: (Adapted from Applicant's Abstract) This is a clinical trial to determine if l-deprenyl can maintain or improve function in community dwelling elderly. The specific aims are to identify a population at-risk to deteriorate cognitively and functionally; to conduct a double-blind parallel- design placebo controlled clinical trial of l-deprenyl; and to assess meaningful outcome measures including progression to dementia and loss of independence in daily activities. The WHICAP project currently assesses residents in the North Manhattan area. Based on the WHICAP evaluation, those who demonstrate cognitive deficits and functional impairments will be asked to participate. Both Spanish and English speaking elderly will be invited to participate. Patients will complete informed consent. Screening and follow-up evaluation will be conducted at the general clinical research center or in the community when necessary. Patients (N=150) will be randomly assigned to one of two conditions; l-deprenyl (10 mgs. per day) or placebo. Assessment will be completed at three month intervals for one year and will include measures of functional independence, assessment of activities of daily living, and quality of life assessments. In addition, brief neuropsychological assessments will also be completed. Parametric and non- parametric techniques will be used to assess drug effect. Endpoint analysis will use progression to dementia and functional independence measures.

描述：（改编自申请人的摘要）这是一项临床试验 确定l-脱发能否维持或改善社区的功能 居住的老年人。 具体目的是确定人口高风险 在认知和功能上恶化；进行双盲 平行设计安慰剂对照l-脱发的临床试验；然后 评估有意义的结果指标，包括进步痴呆和 在日常活动中失去独立性。 WHICAP项目目前评估北曼哈顿的居民 区域。根据WHICAP评估，那些证明认知的人 赤字和功能障碍将被要求参加。 两个都 西班牙语和英语的老年人将被邀请参加。 患者将完成知情同意。 筛查和随访 评估将在一般临床研究中心或IN进行 必要时社区。 患者（n = 150）将随机分配 到两个条件之一； l-脱发（每天10毫克）或安慰剂。 评估将以三个月的间隔完成一年， 将包括功能独立性的度量，评估活动 日常生活和生活质量评估。 此外，简短 神经心理学评估也将完成。参数和非 - 参数技术将用于评估药物效应。端点 分析将使用痴呆症和功能独立性进展 措施。