Alzheimer's Disease Research Center Supplement for VA Collaboration

阿尔茨海默病研究中心 VA 合作补充资料

• 批准号: 10192271
• 负责人: Mary Sano
• 金额: $ 31.44万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192271
• 关键词: Aging; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Awareness; Biological Markers; Caregiver research; Caregivers; Caring; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Trials; Cognitive; Collaborations; Communities; Data; Data Analytics; Data Sources; Dementia; Development; Disease; Doctor of Philosophy; Early Diagnosis; Education; Educational Materials; Educational workshop; Elderly; Eligibility Determination; Enrollment; Evaluation; Faculty; Funding; Geriatric Psychiatry; Geriatrics; Goals; Health; Health care facility; Impaired cognition; Individual; Investigational Therapies; Location; Medical; Medical center; Monitor; Natural History; New York; Outcome; Outreach Research; Participant; Patient Care; Patients; Population; Prevention; Primary Health Care; Provider; Recording of previous events; Records; Registries; Research; Resources; Schedule; Services; Surveys; Veterans; Visit; Work; care seeking; clinical biomarkers; clinical center; cohort; comorbidity; design; disease natural history; disorder prevention; education research; eligible participant; ethnic diversity; experience; human old age (65+); improved; information organization; interest; lectures; medical specialties; meetings; member; novel strategies; outreach; primary care services; racial and ethnic; ranpirnase; recruit; research study; success; tool

This is a request for supplemental funds to the Mount Sinai Alzheimer’s Disease Research Center (MSADRC), PI: Mary Sano, PhD, (P30 AG066514) to pilot novel approaches for effective and sustainable strategies to increase the recruitment and retention of veterans into clinical research studies of Alzheimer’s disease and Alzheimer's disease related dementias (AD/ADRD). This supplemental application enhances several aims of the recently funded ADRC. Building on years of experience with co-location of the MSADRC at the James J Peters VAMC in the Bronx, this supplement proposes to extend outreach and recruitment to cognitively healthy veterans and those with early or subtle cognitive impairment to engage them in research around dementia prevention and early detection of disease. These individuals are most often seen in primary care by the Patient Aligned Care Team (PACT). To target these individuals we propose to use the Bronx Regional Health Information Organization (RHIO), a New York State certified health information exchange, to identify those who are seen at other health facilities in the region. This resource, in combination with the data analytic team at the JJPVAMC, has currently identified over 2700 individuals who may be available to approach for research participation. With the support of primary care we will conduct outreach activities to this cohort in conjunction with their visits with the VA PACT, and invite them to register interest in clinical research in AD/ADRD. We will create a Research Coordination (RC) Team that will use the expertise of the JJP VA Geriatric Research, Education and Clinical Center (GRECC) to create alliances with patients, caregivers and providers. A Veteran and Caregiver Research Advisory Council will be assembled through the GRECC to assist with the development and evaluation of outreach, engagement and educational materials that have been developed by the Outreach and Engagement (ORE) core of the ADRC. The council will provide input for constructing messages to raise awareness of cognitive health and dementia prevention in the veteran community and will suggest topics for lectures and workshops that are relevant to concerns of VA patients and their caregivers. Participants who join the registry will be invited to participate in studies such as natural history and biomarker studies including into the MSADRC clinical Core, clinical trials, survey studies and educational opportunities that will be offered by the MSADRC Outreach Core. The RC team will track registry participants to determine the profile of successfully enrolled subjects and rates of recruitment into specific types of trials. Details such as the number of veterans contacted, referred, screened, successfully enrolled and retained in to AD/ADRD research will be tracked and the data will be used to evaluate and modify outreach efforts to maximize veteran engagement in research. As outcomes, we expect this work to improve recruitment into AD/ADRD related trials with a specific focus on biomarker studies for early disease stage and disease prevention efforts, and to create a roadmap that will permit the success to be reproduced in other centers.

这是向西奈山阿尔茨海默病研究中心 (MSADRC) 提供补充资金的请求， PI：Mary Sano 博士 (P30 AG066514) 试验有效和可持续战略的新方法 增加招募和保留退伍军人参与阿尔茨海默氏病的临床研究， 阿尔茨海默病相关痴呆（AD/ADRD）这一补充应用增强了多个目标。 最近资助的 ADRC 建立在 MSADRC 与 James J 共同办公的多年经验之上。 布朗克斯区的 Peters VAMC，该增刊建议将外展和招募范围扩大到认知健康的人群 退伍军人和患有早期或轻微认知障碍的人让他们参与有关痴呆症的研究 这些人最常在初级保健中看到。 为了针对这些人，我们建议使用布朗克斯地区卫生中心的患者协调护理团队 (PACT)。 信息组织 (RHIO)，纽约州认证的健康信息交换机构，旨在识别那些 该资源与该地区的数据分析团队相结合。 JJPVAMC 目前已确定超过 2700 名可以接触研究的人员 在初级保健的支持下，我们将联合对这一群体开展外展活动。 我们将邀请他们参观 VA PACT，并邀请他们对 AD/ADRD 临床研究感兴趣。 创建一个研究协调 (RC) 团队，该团队将利用 JJP VA 老年研究的专业知识， 教育和临床中心 (GRECC) 与患者、护理人员和退伍军人建立联盟。 和看护者研究咨询委员会将通过 GRECC 组建，以协助 开发和评估由以下机构开发的外展、参与和教育材料 ADRC 的外展和参与 (ORE) 核心将为建设提供投入。 旨在提高退伍军人社区认知健康和痴呆症预防意识的信息以及意愿 建议与 VA 患者及其护理人员关注的问题相关的讲座和研讨会主题。 加入注册中心的参与者将被邀请参加自然历史和生物标志物等研究 研究包括 MSADRC 临床核心、临床试验、调查研究和教育机会 这将由 MSADRC 外展核心提供，RC 团队将跟踪注册管理机构参与者以确定。 成功招募受试者的概况以及特定类型试验的招募率等详细信息。 联系、转介、筛选、成功登记和保留到 AD/ADRD 的退伍军人数量 将跟踪研究，数据将用于评估和修改外展工作，以最大限度地扩大退伍军人的影响 作为成果，我们希望这项工作能够改善 AD/ADRD 相关的招募工作。 特别关注早期疾病阶段和疾病预防工作的生物标志物研究的试验，以及 创建一个路线图，使成功能够在其他中心复制。