Matrix-assisted laser desorption/ionization mass spectrometry imaging for advanced chemical and materials analysis

用于先进化学和材料分析的基质辅助激光解吸/电离质谱成像

基本信息

批准号：
EP/T031301/1
负责人：
Nicholas Lockyer
金额：
$ 103.27万
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FT031301%2F1
关键词：
Matrix assisted laser desorption ionization

项目摘要

Mass spectrometry is an essential tool for molecular structural determination which underpins breakthroughs in Engineering, Physical Sciences and Life Sciences. In Matrix-Assisted Laser Desorption-Ionisation (MALDI) mass spectrometry, samples are analysed in the form of a solid, and surface chemical imaging is possible as part of a growing field in mass spectrometry imaging. Chemical imaging using mass spectrometry fill a critical gap in the materials characterisation toolbox, complementing physical imaging tools e.g. electron microscopy. Unravelling the chemistry of the surface of materials and devices is critical in understanding their interaction with their environment and improving their performance. The facility will provide exquisite detail on chemical structures, together with micrometre precision in spatial distribution. The equipment will support research activities in Engineering & Physical Sciences and Life Sciences, encompassing both industrially relevant projects and blue-sky research. A strategic focus will be on Industrial Biotechnology and Advanced Materials, where analytical tools to characterise large molecules and complex systems are urgently needed in supporting the developing bioeconomy and novel healthcare technologies. Examples include enhanced production of new biopharmaceuticals or biodegradable polymers and wearable technology for medical diagnostics.Our aim is to establish a multi-user analytical facility providing mass spectrometric chemical analysis and imaging. This will be managed, through proven mechanisms and support infrastructure, to maximise institutional, regional and national impact through collaborative research and major national academic-industrial networks.

质谱是分子结构确定的必不可少的工具，在工程，物理科学和生命科学方面取得了突破。在基质辅助激光解吸率（MALDI）质谱法中，样品以固体的形式进行分析，并且可以作为质谱成像中生长领域的一部分表面化学成像。使用质谱法化学成像填补了材料表征工具箱中的关键空白，补充了物理成像工具，例如电子显微镜。阐明材料和设备表面的化学反应对于理解它们与环境的相互作用并改善其性能至关重要。该设施将提供有关化学结构的精美细节，以及空间分布的微米精度。该设备将支持工程和物理科学和生命科学领域的研究活动，涵盖与工业相关的项目和蓝光研究。战略重点将放在工业生物技术和高级材料上，在该材料中，在支持发展中的生物经济经济和新型医疗保健技术时，迫切需要表征大分子和复杂系统的分析工具。例子包括增强新生物药物或可生物降解聚合物的生产以及用于医学诊断的可穿戴技术。我们的目的是建立一个多用户分析设施，提供质谱化学分析和成像。这将通过经过验证的机制和支持基础设施来管理，以通过合作研究和主要的国家学术工业网络最大化机构，区域和国家的影响。