PEDIATRIC ONCOLOGY GROUP

儿科肿瘤组

• 批准号: 3555848
• 负责人: TERESA J. VIETTI
• 金额: $ 17.98万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3555848
• 关键词: 6 thioguanine; 6 thiopurine; Ewing's tumor; Hodgkin's disease; asparaginase; aziridines; brain neoplasms; carmustine; central nervous system neoplasms; child (0-11); cis platinum compound; combination cancer therapy; combination chemotherapy; cooperative study; cortisol; cyclophosphamide; cytosine arabinoside; dacarbazine; daunorubicin; doxorubicin; drug adverse effect; ependymoma; fluorouracil; glioma; human subject; human therapy evaluation; leucovorin; lomustine; lymphocytic leukemia; lymphoma; methotrexate; mitomycin C; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer classification /staging; neoplasm /cancer immunology; neoplasm /cancer radiation therapy; nephroblastoma; osteosarcoma; pediatric neoplasm /cancer; prednisone; rhabdomyosarcoma; sarcoma; streptozotocin; teratoma; vinblastine; vincristine

The Children's Cancer Center at St. Louis Children's Hospital, Washington University School of Medicine, is one of the 40 institutions and 24 affiliate institutions of the Pediatric Oncology Group who have pooled their patient resources and scientific expertise to study the natural history of childhood cancer, develop and compare effective therapeutic regimens and investigate the toxicity and effectiveness of new anticancer agents in the treatment of children with cancer. The investigators at Washington University include pediatric oncologists, radiologists, radiation therapists, neurologists, surgeons, and pathologists. All children with malignant disease are placed on cooperative group protocols if they are eligible, after informed consent is obtained. Data that is accessioned at the time the patient is placed on study protocol, during the study, and when off therapy is submitted to the Group statistical office for data analysis, interpretation and presentation. The investigators at Washington University serve in multiple administrative and research capacities for the group. The diagnostic studies, pathological findings, surgical procedure and therapeutic plan for all new patients and patients who relapse are discussed at the weekly Tumor Board Conference. Access to intensive multimodal therapy and experiment compounds is facilitated by the close contact of the center with the nearby Pediatric Oncology Group Operations Office, of which the Principal Investigator is Group Chairman. The acting principal investigator directs the effort whereby Washington University investigators review spinal fluid slides of all pediatric oncology patients to confirm the diagnosis of central nervous system leukemia, and the laboratories of two other investigators serve as Pediatric Oncology Group reference laboratories for the study of neuroblastoma tumors for N-myc and N-ras oncogene inactivation, and for the establishment of lymphoblastoid cell lines from patients so studied.

华盛顿圣路易斯儿童医院的儿童癌症中心 大学医学院是40家机构之一，有24个机构之一 小儿肿瘤学集团的会员机构 他们的患者资源和科学专业知识来研究自然 儿童癌症的史，发展和比较有效的治疗 方案并研究新抗癌的毒性和有效性 治疗癌症儿童的药物。 调查人员在 华盛顿大学包括儿科肿瘤学家，放射科医生， 放射治疗师，神经病学家，外科医生和病理学家。 全部 患有恶性疾病的儿童被放在合作组方案上 如果获得知情同意后，则有资格。 数据就是 在患者被置于研究方案时，在 研究，当不接受治疗提交给小组统计办公室时 用于数据分析，解释和呈现。 调查人员在 华盛顿大学在多个行政和研究中任职 该小组的能力。 诊断研究，病理发现， 所有新患者和患者的手术程序和治疗计划 在每周的肿瘤委员会会议上讨论了谁复发。 访问 强化的多模式疗法和实验化合物促进了 中心与附近的儿科肿瘤学组密切接触 运营办公室，主要研究人员是集团主席。 代理首席调查员指导华盛顿的努力 大学调查人员回顾所有儿科的脊柱流体幻灯片 肿瘤患者确认中枢神经系统的诊断 白血病和另外两个研究人员的实验室作为 小儿肿瘤学组参考实验室 N-MYC和N-RAS癌基因灭活的神经母细胞瘤肿瘤，以及用于 从如此研究的患者中建立淋巴母细胞细胞系。