CHILDREN'S CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3556230
• 负责人: PHILIP P BREITFELD
• 金额: $ 15.71万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3556230
• 关键词: 6 thioguanine; 6 thiopurine; Ewing's tumor; Mycobacterium bovis; acute leukemia; acute lymphocytic leukemia; antineoplastics; asparaginase; autologous transplantation; bone marrow transplantation; cellular oncology; central nervous system; child (0-11); combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytogenetics; cytosine arabinoside; daunorubicin; doxorubicin; drug adverse effect; drug resistance; flow cytometry; gene expression; gene frequency; germ cell neoplasms; human subject; human therapy evaluation; immunosuppression; interleukin 4; lymphoma; lymphosarcoma; methotrexate; molecular oncology; myelogenous leukemia; natural gene amplification; neoplasm /cancer chemotherapy; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; neoplasm /cancer immunotherapy; neoplasm /cancer radionuclide therapy; neoplasm /cancer surgery; nephroblastoma; neuroblastoma; nutrition aspect of cancer; oncogenes; osteosarcoma; pediatric neoplasm /cancer; postoperative state; prednisone; radionuclide imaging /scanning; rhabdomyosarcoma; vincristine

This is an application for the continued support of Indiana University's participation in Children's Cancer Study Group scientific activities. The specific aims of the project will be to register and enter all eligible patients on Children's Cancer Study Group protocols with the final goal of achieving an improved rate of survival. Our large patient population provides an important source of study subjects for the CCSG. With optimal accrual and the opening of new protocols, it is estimated that the Indiana University network will place 150-160 patients per year on children's Cancer Study Group protocols. The Indiana University network will continue to follow and provide data on 1,033 patients (Indiana 726 an affiliate network 307) currently on CCSG therapeutic studies or in follow-up of these studies. Indiana University will participate in all phases of clinical cancer research with the Children's Cancer Study Group, including epidemiology studies, cancer biology studies, special studies, new agent studies, pilot studies, therapeutic studies, and long-term follow-up/late effects studies. Our investigators are experienced and skilled with regard to the implementation of CCSG protocols. Indiana University investigators will provide scientific leadership in the areas of cytogenetics, bone tumors, acute lymphocytic leukemia, Wilm's tumor neuroblastoma, non-hodgkin's lymphoma, germ cell tumor, tumor imaging, molecular and cellular biology, surgical oncology radiation oncology nutrition support, and bone marrow transplant. Emphasis will be placed on improved participation in the areas of new agent studies, epidemiology studies, special studies and long-term follow-up/late effects studies. Specific plans for expanding Indiana University CCSG participation include the areas of bone marrow transplantation, cytogenetics, tumor imaging, molecular and cellular biology, nutritional support, and the incorporation of Indiana University research resource capabilities into CCSG activities, Indiana University personnel are dedicated to protocol compliance to insure quality clinical research in childhood cancer so that valid conclusions can be drawn form each important CCSG study.

这是一份持续支持印第安纳州的申请 大学参与儿童癌症研究小组 科学活动。 该项目的具体目标是 登记并输入所有符合条件的儿童癌症患者 研究组协议的最终目标是实现改进 生存率。 我们庞大的患者群体提供了 CCSG 研究主题的重要来源。 具有最优 权责发生制和新协议的启用，估计 印第安纳大学网络每年将安排 150-160 名患者参加 儿童癌症研究小组协议。 印第安纳大学 网络将继续追踪并提供1,033名患者的数据 （印第安纳州 726 联属网络 307）目前在 CCSG 上 治疗研究或这些研究的后续研究。 印第安纳州 大学将参与临床癌症的各个阶段 与儿童癌症研究小组的研究，包括 流行病学研究、癌症生物学研究、特殊研究、新 药物研究、试点研究、治疗研究和长期研究 后续/后期影响研究。 我们的调查员经验丰富 并熟练实施 CCSG 协议。 印第安纳大学研究人员将提供科学领导 在细胞遗传学、骨肿瘤、急性淋巴细胞白血病等领域 白血病、肾母细胞瘤、神经母细胞瘤、非霍奇金淋巴瘤、细菌 细胞肿瘤、肿瘤成像、分子和细胞生物学、外科 肿瘤学 放射肿瘤学 营养支持和骨髓 移植。 重点将放在改善参与 新剂研究、流行病学研究、特殊领域 研究和长期随访/后期影响研究。 具体的 扩大印第安纳大学 CCSG 参与的计划包括 骨髓移植、细胞遗传学、肿瘤领域 成像、分子和细胞生物学、营养支持，以及 印第安纳大学研究资源的整合 印第安纳大学人员将能力融入 CCSG 活动 致力于方案合规性以确保临床质量 对儿童癌症进行研究，以便得出有效的结论 形成每项重要的 CCSG 研究。