AIDS CLINICAL STUDY GROUP

艾滋病临床研究组

• 批准号: 3546973
• 负责人: ROBERT J FASS
• 金额: $ 149.1万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3546973
• 关键词: AIDS; human immunodeficiency virus 1; human subject

The overall goals of this AIDS-CSG are to establish a clinical center for the treatment of HIV infection and related disorders in the OSU Hospitals referral area and to establish a related multidisciplinary basic research effort. Specific objectives include: 1. Establish a cohort of HIV infected patients. 2. Establish a local core of clinical and basic scientists committed to studying this infection. 3. Enter as many of our cohorts as possible into our General Clinical Research Center database - CLINFO. 4. Conduct therapeutic interventions during various stages of HIV infection and follow the course of infection after intervention. 5. Provide adequate resources for the diagnosis and treatment of HIV related conditions such as opportunistic infections and malignancies. 6. Conduct basic science projects to study the epidemiology, pathogenesis, immunology and natural history of HIV infection. 7. Have the cohort available for future studies. Project 1 establishes a cohort of patients, tracks the course of HIV infection, provides the clinical database for other projects, and tests the efficacy and safety of investigational treatments for opportunistic infections. Project 2 tests the potential of alpha-, beta- and gamma-interferons, in combination with AZT, as therapeutic agents. Project 3 tests the hypothesis that vasoactive intestinal peptide (VIP) or other peptides may be responsible for HIV associated diarrhea. Project 5 will assess the effects of HIV infections on Ia expression by human monocytes, the effects of AZT treatment on Ia expression and the ability of monocytes from infected individuals to control growth of MAC. Support services will be supplied by an administrative core, a laboratory core, and a database and analysis core.

此AIDS-CSG的总体目标是建立临床 艾滋病毒感染和相关疾病的治疗中心 OSU医院推荐区域并建立相关 多学科基础研究工作。 特定目标 包括： 1。建立一组HIV感染的患者。 2。建立临床和基础科学家的本地核心 致力于研究这种感染。 3。尽可能多地进入我们的一般人群 临床研究中心数据库-Clinfo。 4。在艾滋病毒的各个阶段进行治疗干预措施 干预后感染并遵循感染过程。 5。提供足够的资源来诊断和治疗 与HIV相关的疾病，例如机会性感染和 恶性肿瘤。 6.进行基础科学项目以研究流行病学， HIV感染的发病机理，免疫学和自然史。 7。有可用于未来研究的队列。 项目1建立了一系列患者，跟踪 HIV感染，为其他项目提供临床数据库， 并测试研究治疗的功效和安全性 机会性感染。 项目2测试α-的潜力 β-和伽马 - 互换，与AZT结合使用 治疗剂。 项目3检验了血管活性的假设 肠肽（VIP）或其他肽可能是造成的 艾滋病毒相关的腹泻。 项目5将评估艾滋病毒的影响 人类单核细胞对IA表达的感染， AZT治疗IA表达和单核细胞的能力 感染的个体控制MAC的生长。 支持服务 将由行政核心，实验室核心和 数据库和分析核心。