Biodegradable hybrid screws for ligament-bone interface regeneration

用于韧带-骨界面再生的可生物降解混合螺钉

• 批准号: EP/S025782/1
• 负责人: Julian Jones
• 金额: $ 142.71万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS025782%2F1
• 关键词: Biodegradable; hybrid; screws; ligament; bone

Anterior Cruciate Ligament injuries are often in the news as they are potentially career ending for footballers and athletes. One of the well-known incidents was seen during 2006 World Cup match between England and Sweden, where Michael Owen ruptured his ACL. This is not just a problem for elite athletes. Approximately 20,000 people in the UK need ACL repair every year and the National Health Service (NHS) performs about 11,000 ACL reconstruction surgeries per year.Reconstructive surgery of the ACL usually involves harvesting replacement ACL graft from the patient's own hamstring tendons. The damaged ACL is removed through arthroscopy (keyhole surgery), then tunnels are drilled in femur (thigh bone) and tibia (shin bone) in the knee joint area. The replacement graft is aligned/positioned through the tunnels, and opposite ends are fixated in the tibial bone tunnel by interference screws. Our clinicians and our medical device partner Xiros have identified an unmet clinical need for new screws and ACL reconstruction devices. Current metallic screws will be eventually rejected by the body as they are bioinert and will undergo fibrous encapsulation, but they can also tear the graft. The aim here is to develop an ideal screw that would be bioactive, to stimulate bonding to bone and regeneration of the connective tissue/ bone interface and biodegradable integrating the graft into the bone. The screw must also be strong, tough and a certain stiffness. Biodegradable polymer/bioactive ceramic composite screws exist, but they often fail and need replacing. This is because the bioactive component is buried in the polymer and the degradation rate of the polymer is uncontrolled and can be catastrophic or cause cysts. Our hybrid screws will overcome those problems, giving strength and a specifically designed biodegradation rate to match the rate of restoration of the bone/connective tissue interface. In some cases, it is not the screw that fails, but the tendon graft, therefore we will also develop a new totally synthetic device that eliminates the need for harvesting from the hamstring and provides more reliable long term performance, while integrating with the host bone.

前十字韧带受伤经常出现在新闻中，因为这可能会导致足球运动员和运动员的职业生涯结束。其中一件著名的事件发生在 2006 年世界杯英格兰队与瑞典队的比赛中，迈克尔·欧文 (Michael Owen) 十字韧带断裂。这不仅仅是精英运动员的问题。英国每年大约有 20,000 人需要 ACL 修复，英国国家医疗服务体系 (NHS) 每年进行大约 11,000 例 ACL 重建手术。ACL 重建手术通常涉及从患者自身的腿筋肌腱获取替代 ACL 移植物。通过关节镜检查（锁孔手术）切除受损的 ACL，然后在膝关节区域的股骨（大腿骨）和胫骨（小腿骨）中钻孔。替换移植物通过隧道对齐/定位，并且相对端通过干涉螺钉固定在胫骨隧道中。我们的临床医生和医疗设备合作伙伴 Xiros 发现了新螺钉和 ACL 重建设备的临床需求尚未得到满足。目前的金属螺钉最终会被身体排斥，因为它们具有生物惰性并且会经历纤维包裹，但它们也会撕裂移植物。这里的目的是开发一种具有生物活性的理想螺钉，以刺激与骨的粘合和结缔组织/骨界面的再生，以及将移植物可生物降解地整合到骨中。螺钉还必须坚固、坚韧并具有一定的刚度。存在可生物降解聚合物/生物活性陶瓷复合螺钉，但它们经常失效并需要更换。这是因为生物活性成分埋藏在聚合物中，并且聚合物的降解速率不受控制，并且可能是灾难性的或导致囊肿。我们的混合螺钉将克服这些问题，提供强度和专门设计的生物降解率，以匹配骨/结缔组织界面的恢复率。在某些情况下，失效的不是螺钉，而是肌腱移植物，因此我们还将开发一种新的全合成装置，无需从腿筋上获取，并提供更可靠的长期性能，同时与宿主骨整合。

项目成果

3D printed hybrid for articular cartilage regeneration: from design to

用于关节软骨再生的 3D 打印混合体：从设计到

• 发表时间: 2023
• 期刊: TISSUE ENGINEERING PART A
• 影响因子: 4.1
• 作者: Tallia Francesca

Training Surgeons to Perform Arthroscopic All-Inside Meniscal Repair: A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Cognitive Task Analysis Teaching Tool, Imperial College London/University College London Meniscus Repair Cognitive Task Analysis (IUMeRCTA).

• DOI: 10.1177/03635465211021652
• 发表时间: 2021-07
• 期刊: The American journal of sports medicine
• 作者: Karamchandani U;Bhattacharyya R;Patel R;Oussedik S;Bhattacharya R;Gupte C
• 通讯作者: Gupte C

3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution.

• DOI: 10.1002/adhm.202100117
• 发表时间: 2021-06
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Chung JJ;Yoo J;Sum BST;Li S;Lee S;Kim TH;Li Z;Stevens MM;Georgiou TK;Jung Y;Jones JR
• 通讯作者: Jones JR

Differences between infected and noninfected synovial fluid.

• DOI: 10.1302/2046-3758.101.bjr-2020-0285.r1
• 发表时间: 2021-01
• 期刊: Bone & joint research
• 影响因子: 4.6
• 作者: Akhbari P;Jaggard MK;Boulangé CL;Vaghela U;Graça G;Bhattacharya R;Lindon JC;Williams HRT;Gupte CM
• 通讯作者: Gupte CM

Bioactive, Degradable and Tough Hybrids Through Calcium and Phosphate Incorporation

通过掺入钙和磷酸盐形成具有生物活性、可降解且坚韧的混合物

• DOI: 10.3389/fmats.2022.901196
• 发表时间: 2022
• 期刊: Frontiers in Materials
• 影响因子: 3.2
• 作者: Tallia F