CAREER: Hybrid Surface Coating Toward Corrosion-Controlled Magnesium-Based Implants

职业：针对腐蚀控制镁基植入物的混合表面涂层

• 批准号: 2339911
• 负责人: Hamdy Ibrahim
• 金额: $ 55.68万
• 依托单位: University of Tennessee Chattanooga
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-05-15 至 2029-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2339911&HistoricalAwards=false
• 关键词: CAREER; Hybrid; Surface; Coating; Toward

NON-TECHNICAL SUMMARYThere is an increasing incidence of bone fractures in the United States, which is caused in part by an aging population. The global market for fracture fixation devices (e.g., medical implants) is expected to reach $13.6 billion by 2027, growing at a compound annual growth rate of 6.1% over that time. This Faculty Early Career Development (CAREER) award addresses a significant healthcare challenge by enhancing the clinical feasibility of biodegradable magnesium-based metallic implants. The utilization of biodegradable implants in biomedical applications, including vascular stents and small bone fixation devices, presents an innovative alternative to the currently employed permanent metallic implants. These permanent metallic implants often entail significant complications and may necessitate surgical intervention. Although biodegradable magnesium-based implants hold promise, their rapid degradation undermines their efficacy before the completion of the healing process. This project introduces innovative hybrid coatings, combining different coating methods and materials, to mitigate degradation and allow the controlled release of bioactive agents. By investigating how bioactive agents interact with coated magnesium, the project aims to understand degradation inhibition mechanisms and modulate degradation rates. Additionally, a computational model will be developed to predict degradation and agent release, bridging theory and experiment. The significance of this research lies in its potential to revolutionize patient-specific biomedical implants by tailoring the degradation rates and hence the lifespan of an implant. Successful outcomes may lead to the improvement of a variety of implants including orthopedic, facial, oral, and more, benefiting patients with personalized needs. This project aligns with the NSF's mission by advancing science, promoting health, and contributing to national welfare. Recognizing the underrepresentation of certain groups, the project includes a community-based mentoring program that aims to expose underserved Hispanic children in Chattanooga and the Southeast Tennessee Area to STEM through hands-on activities, fostering engagement and civic involvement. The PI also plans to work with the Society of Women Engineers at the university to introduce female high school students to biomedical engineering research, encouraging their participation in STEM fields. Moreover, a graduate course on "Manufacturing of Biomaterials" will be developed, enriching education and nurturing future professionals.TECHNICAL SUMMARYThis research project addresses the challenge of rapid degradation in magnesium-based biomedical implants, hindering their clinical impact. By employing hybrid coating systems, particularly plasma electrolytic oxidation (PEO) coupled with the sol-gel coating method, the project aims to control degradation rates and enhance bioactive agent release for smart biomaterials. This research project will address gaps in understanding the mechanisms behind enhanced corrosion resistance of coated magnesium implants and the effective regulation of bioactive agent release during prolonged implantation periods. Two primary objectives guide the investigation: Objective #1 focuses on understanding the interaction of bioactive agents with the porous surface of PEO-coated magnesium substrates, elucidating their role as corrosion inhibitors through microstructural evolution and electrochemical corrosion mechanisms. Objective #2 involves the development of a versatile numerical model based on a physical modeling approach to predict degradation rates and bioactive agent release from magnesium substrates coated with hybrid PEO-based and multiple layers of hydroxyapatite (HA) sol-gel coatings. One outcome of the project is the possibility of depositing thin ( 100 nm) subsequent coating layers. That enables the establishment of a clear relationship between the deposited coating layers and degradation rates. This understanding is crucial for ensuring a time-certain commencement of the implant’s degradation, a vital aspect for patient-specific implant applications. The interdisciplinary approach combines expertise in biomaterials processing, corrosion science, and numerical modeling. The anticipated outcomes hold the potential to integrate magnesium as a biodegradable metal technology in clinical settings, particularly for patient-specific devices in orthopedic and craniomaxillofacial applications. The educational objective of the project is to (1) develop a new community-based mentoring program for Hispanic children ages 11 to 18, (2) organize talks, presentations, and live demonstrations aiming at recruiting more female research students, and (3) develop a graduate interdisciplinary course on the topic of “Manufacturing of Biomaterials”. These educational activities will offer STEM exposure, social engagement, career development, and advising, particularly for Hispanic and female students in Chattanooga and the Southeast Tennessee Area.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要在美国的骨骼碎片发生率越来越多，这部分是由人口老龄化引起的。到2027年，全球骨折固定设备的全球市场（例如，医疗固定设备）预计将达到136亿美元，在此期间以6.1％的复合年增长率增长。该教师早期职业发展（职业）奖通过增强可生物降解的基于镁的金属灌注的临床可行性来解决重大的医疗挑战。在包括血管支架和小骨骼固定装置在内的生物医学应用中，可生物降解的牙齿的利用提供了一种创新的替代品，用于当前使用的永久金属螺想体。这些永久的金属螺想体通常会带来严重的并发症，并可能需要手术干预。尽管可生物降解的镁基础有望有望，但它们的迅速降解会在愈合过程完成之前的有效性。该项目引入了创新的混合涂料，结合了不同的涂料方法和材料，以减轻降解并允许受控生物活性剂的释放。通过研究生物活性剂如何与涂层镁相互作用，该项目旨在了解降解机制并调节降解速率。此外，将开发一个计算模型，以预测降解和代理释放，桥接理论和实验。这项研究的意义在于它通过调整降解率并因此植入物的寿命来彻底改变患者特异性生物医学的潜力。成功的结果可能会导致各种武器的改善，包括骨科，面部，口服以及更多，使有个性化需求的患者受益。该项目通过推进科学，促进健康并为国家福利做出贡献来与NSF的使命保持一致。该项目认识到某些群体的代表性不足，包括一个基于社区的心理计划，旨在揭露查塔努加和田纳西州东南部地区的西班牙裔儿童，通过动手活动，促进参与和公民参与。 PI还计划与大学的女工程师协会合作，向女性高中学生介绍生物医学工程研究，并鼓励她们参与STEM领域。此外，将开发有关“生物材料制造”的研究生课程，以丰富教育并培养未来的专业人员。技术摘要这项研究项目解决了基于镁的生物医学影响的快速退化的挑战，阻碍了其临床影响。通过采用混合涂料系统，尤其是血浆电解氧化（PEO），再加上Sol-Gel涂层方法，该项目旨在控制降解速率并增强智能生物材料的生物活性剂释放。该研究项目将解决理解涂层镁的增强腐蚀性背后的机制的差距，并有效调节生物活性剂在延长的植入期间的释放。两个主要目标指导投资：目标＃1专注于理解生物活性剂与PEO涂层镁底物的多孔表面的相互作用，从而阐明了它们通过微结构进化和电化学腐蚀机制来阐明其作为腐蚀抑制剂的作用。目标＃2涉及基于物理建模方法的多功能数值模型的开发，以预测从涂有基于混合PEO的镁和多层羟基（HA）Sol-gel涂层的镁基质中释放出降解速率和生物活性剂。该项目的一个结果是将薄（100 nm）随后的涂层层存放的可能性。这样可以建立沉积的涂层层与降解率之间的明确关系。这种理解对于确保植入物降解的时间开始至关重要，这是患者特异性植入物应用的重要方面。跨学科方法结合了生物材料处理，腐蚀科学和数值建模方面的专业知识。预期的结果有可能在临床环境中将镁作为可生物降解的金属技术整合，尤其是对于骨科和颅面上的患者特定设备而言。该项目的教育目标是（1）针对11至18岁的西班牙裔儿童制定新的基于社区的心理计划，（2）组织会谈，演示和现场演示旨在招募更多的女性研究专业的学生，​​以及（3）开发一个有关“生物物质制造”主题的毕业生跨学科课程。这些教育活动将提供STEM暴露，社交参与，职业发展和咨询，特别是对于查塔努加（Chattanooga）和田纳西州东南部地区的西班牙裔和女学生。这项奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来评估而被认为是珍贵的支持。