CAREER: Hybrid Surface Coating Toward Corrosion-Controlled Magnesium-Based Implants

职业：针对腐蚀控制镁基植入物的混合表面涂层

• 批准号: 2339911
• 负责人: Hamdy Ibrahim
• 金额: $ 55.68万
• 依托单位: University of Tennessee Chattanooga
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-05-15 至 2029-04-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2339911&HistoricalAwards=false
• 关键词: CAREER; Hybrid; Surface; Coating; Toward

NON-TECHNICAL SUMMARYThere is an increasing incidence of bone fractures in the United States, which is caused in part by an aging population. The global market for fracture fixation devices (e.g., medical implants) is expected to reach $13.6 billion by 2027, growing at a compound annual growth rate of 6.1% over that time. This Faculty Early Career Development (CAREER) award addresses a significant healthcare challenge by enhancing the clinical feasibility of biodegradable magnesium-based metallic implants. The utilization of biodegradable implants in biomedical applications, including vascular stents and small bone fixation devices, presents an innovative alternative to the currently employed permanent metallic implants. These permanent metallic implants often entail significant complications and may necessitate surgical intervention. Although biodegradable magnesium-based implants hold promise, their rapid degradation undermines their efficacy before the completion of the healing process. This project introduces innovative hybrid coatings, combining different coating methods and materials, to mitigate degradation and allow the controlled release of bioactive agents. By investigating how bioactive agents interact with coated magnesium, the project aims to understand degradation inhibition mechanisms and modulate degradation rates. Additionally, a computational model will be developed to predict degradation and agent release, bridging theory and experiment. The significance of this research lies in its potential to revolutionize patient-specific biomedical implants by tailoring the degradation rates and hence the lifespan of an implant. Successful outcomes may lead to the improvement of a variety of implants including orthopedic, facial, oral, and more, benefiting patients with personalized needs. This project aligns with the NSF's mission by advancing science, promoting health, and contributing to national welfare. Recognizing the underrepresentation of certain groups, the project includes a community-based mentoring program that aims to expose underserved Hispanic children in Chattanooga and the Southeast Tennessee Area to STEM through hands-on activities, fostering engagement and civic involvement. The PI also plans to work with the Society of Women Engineers at the university to introduce female high school students to biomedical engineering research, encouraging their participation in STEM fields. Moreover, a graduate course on "Manufacturing of Biomaterials" will be developed, enriching education and nurturing future professionals.TECHNICAL SUMMARYThis research project addresses the challenge of rapid degradation in magnesium-based biomedical implants, hindering their clinical impact. By employing hybrid coating systems, particularly plasma electrolytic oxidation (PEO) coupled with the sol-gel coating method, the project aims to control degradation rates and enhance bioactive agent release for smart biomaterials. This research project will address gaps in understanding the mechanisms behind enhanced corrosion resistance of coated magnesium implants and the effective regulation of bioactive agent release during prolonged implantation periods. Two primary objectives guide the investigation: Objective #1 focuses on understanding the interaction of bioactive agents with the porous surface of PEO-coated magnesium substrates, elucidating their role as corrosion inhibitors through microstructural evolution and electrochemical corrosion mechanisms. Objective #2 involves the development of a versatile numerical model based on a physical modeling approach to predict degradation rates and bioactive agent release from magnesium substrates coated with hybrid PEO-based and multiple layers of hydroxyapatite (HA) sol-gel coatings. One outcome of the project is the possibility of depositing thin ( 100 nm) subsequent coating layers. That enables the establishment of a clear relationship between the deposited coating layers and degradation rates. This understanding is crucial for ensuring a time-certain commencement of the implant’s degradation, a vital aspect for patient-specific implant applications. The interdisciplinary approach combines expertise in biomaterials processing, corrosion science, and numerical modeling. The anticipated outcomes hold the potential to integrate magnesium as a biodegradable metal technology in clinical settings, particularly for patient-specific devices in orthopedic and craniomaxillofacial applications. The educational objective of the project is to (1) develop a new community-based mentoring program for Hispanic children ages 11 to 18, (2) organize talks, presentations, and live demonstrations aiming at recruiting more female research students, and (3) develop a graduate interdisciplinary course on the topic of “Manufacturing of Biomaterials”. These educational activities will offer STEM exposure, social engagement, career development, and advising, particularly for Hispanic and female students in Chattanooga and the Southeast Tennessee Area.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要 美国骨折发生率不断上升，部分原因是人口老龄化。预计到 2027 年，骨折固定装置（例如医疗植入物）的全球市场将达到 136 亿美元，增长率为在此期间，该教师早期职业发展 (CAREER) 奖项的复合年增长率为 6.1%，通过提高可生物降解的镁基金属的临床可行性，解决了重大的医疗保健挑战。可生物降解植入物在生物医学应用中的应用，包括血管支架和小型骨固定装置，为目前使用的永久性金属植入物提供了一种创新的替代方案，尽管可生物降解的镁-植入物通常会带来严重的并发症，并且可能需要手术干预。基于植入物的前景广阔，但在愈合过程完成之前，它们的快速降解会破坏其功效。该项目引入了创新的混合涂层，结合了不同的涂层方法和材料，以减轻降解并允许生物活性剂的受控释放。通过研究生物活性剂如何与涂层镁相互作用，该项目旨在了解降解抑制机制并调节降解率，此外，还将开发一个计算模型来预测降解和试剂释放，桥接理论和实验。它具有通过定制植入物的降解率和使用寿命来彻底改变患者特定生物医学植入物的潜力，成功的结果可能会导致包括骨科、面部、口腔等在内的各种植入物的改进，从而使具有个性化需求的患者受益。这该项目通过推进科学、促进健康和为国家福利做出贡献，与 NSF 的使命相一致。认识到某些群体的代表性不足，该项目包括一项基于社区的指导计划，旨在让查塔努加和田纳西州东南部地区服务不足的西班牙裔儿童了解更多信息。通过实践活动开展 STEM，促进参与和公民参与。PI 还计划与大学女工程师协会合作，向女高中生介绍生物医学工程研究，鼓励她们参与 STEM 领域。此外，还将开发“生物材料制造”研究生课程，丰富教育并培养未来的专业人员。技术摘要该研究项目解决了镁基生物医学植入物快速降解的挑战，通过采用混合涂层系统，阻碍了其临床影响。该项目特别是等离子体电解氧化（PEO）与溶胶凝胶涂层方法相结合，旨在控制智能生物材料的降解速率并增强生物活性剂的释放。了解涂层镁植入物增强耐腐蚀性的机制以及在长时间植入期间有效调节生物活性剂释放的两个主要目标指导研究：目标#1侧重于了解生物活性剂与PEO涂层多孔表面的相互作用。目标#2涉及开发基于物理建模方法的通用数值模型，以预测涂有混合材料的镁基材的降解率和生物活性剂释放。基于 PEO 的多层羟基磷灰石 (HA) 溶胶-凝胶涂层该项目的成果之一是能够沉积薄（100 nm）的后续涂层，从而能够在沉积的涂层和降解之间建立明确的关系。这种理解对于植入物在一定时间内开始降解至关重要，这是确保患者特定植入物应用的重要方面。跨学科方法结合了生物材料加工、腐蚀科学和数值建模方面的专业知识。该项目的教育目标是 (1) 为 11 岁至 11 岁的西班牙裔儿童制定新的基于社区的指导计划。 18，（2）组织讲座、演讲和现场演示，旨在招募更多女性研究生，（3）开发以“生物材料制造”为主题的研究生跨学科课程。将提供 STEM 接触、社会参与、职业发展和建议，特别是针对查塔努加和田纳西州东南部地区的西班牙裔和女学生。该奖项是 NSF 的法定使命，通过使用基金会的智力优点和更广泛的评估进行评估，被认为值得支持影响审查标准。