STRUCTURE AND FUNCTION OF LUCIFERASE

荧光素酶的结构和功能

• 批准号: 3287238
• 负责人: BRIAN W MATTHEWS
• 金额: $ 6.47万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1990-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3287238
• 关键词: Vibrio; X ray crystallography; electron density; enzyme mechanism; enzyme structure; luciferin monooxygenase; photochemistry

Our objective is to determine the three-dimensional structure of bacterial luciferase by the method of X-ray crystallography. Recent success in obtaining large crystals of the protein makes this a feasible undertaking. This will be the first known structure of any bioluminescent system and will be a major step toward understanding the phenomenon of light emission. The study will also contribute to our understanding of the structure and function of biological systems in general and flavin-proteins in particular.

我们的目标是确定细菌的三维结构 通过X射线晶体学方法检测荧光素酶。 最近的成功 获得大的蛋白质晶体使这成为一项可行的任务。 这将是第一个已知的生物发光系统结构 这将是理解光发射现象的重要一步。 这项研究还将有助于我们理解结构和 一般生物系统的功能，特别是黄素蛋白的功能。