Photo-Electro: Transforming Chemical Synthesis, Discovery and Manufacture

光电：改变化学合成、发现和制造

• 批准号: EP/P013341/1
• 负责人: Mike George
• 金额: $ 826.5万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP013341%2F1
• 关键词: Photo; Electro; Transforming; Chemical; Synthesis

Our vision is to use continuous photochemistry and electrochemistry to transform how fine chemicals, agrochemicals and pharmaceuticals are manufactured in the UK. We aim to minimize the amount of chemicals, solvents and processing steps needed to construct complex molecules. We will achieve this by exploiting light and/or electricity to promote more specific chemical transformations and cleaner processes. By linking continuous photochemistry and electro-chemistry with thermal flow chemistry and environmentally acceptable solvents, we will create a toolkit with the power to transform all aspects of chemical synthesis from initial discovery through to chemical manufacturing of high-value molecules. The objective is to increase efficiency in terms of both atoms and energy, resulting in lower cost, low waste, low solvent footprints and shorter manufacturing routes. Historically photo- and electro-chemistry have been under-utilised in academia and industry because they are perceived to be complicated to use, difficult to scale up and engineer into viable processes despite their obvious environmental, energy and cost benefits. We will combine the strategies and the skills needed to overcome these barriers and will open up new areas of science, and deliver a step-change (i) providing routes to novel molecular architectures, hard to reach or even inaccessible by conventional methodologies, (ii) eliminating many toxic reagents by rendering them unnecessary, (iii) minimizing solvent usage, (iv) promoting new methodologies for synthetic route planning. Our proposal is supported by 21 industrial partners covering a broad range of sectors of the chemistry-using industries who are offering £1.23M in-kind support.Therefore, we will study a broad range of reactions to provide a clear understanding of the most effective areas for applying our techniques; we will evaluate strategies for altering the underlying photophysics and kinetics so as to accelerate the efficiency of promising reactions; we will transform our current designs of photochemical and electrochemical reactors, with a combination of engineering, modelling and new fabrication techniques to maximize their efficiency and to provide clear opportunities for scale-up; we will exploit on-line analytics to accelerate the optimisation of continuous photochemical and electrochemical reactions; we will design and build a new generation of reactors for new applications; we will identify the most effective strategies for linking our reactors into integrated multi-step continuous processes with minimized waste; we will demonstrate this integration on at least one synthesis of a representative pharmaceutical target molecule on a larger scale; we will apply a robust series of sustainability metrics to benchmark our approaches against current manufacturing.

我们的愿景是利用连续光化学和电化学来改变英国精细化学品、农用化学品和药品的生产方式。我们的目标是最大限度地减少构建复杂分子所需的化学品、溶剂和加工步骤。我们将通过利用光来实现这一目标。通过将连续光化学和电化学与热流化学和环境可接受的溶剂联系起来，我们将创建一个能够改变化学各个方面的工具包。从最初的发现到高价值分子的化学制造，其目标是提高原子和能量的效率，从而降低成本、减少浪费、减少溶剂足迹并缩短历史上的光和电子制造路线。化学在学术界和工业界并未得到充分利用，因为尽管它们具有明显的环境、能源和成本效益，但它们被认为使用复杂、难以扩大规模和设计成可行的工艺。我们将结合克服所需的策略和技能。这些障碍将开辟新的科学领域，并实现逐步改变（i）提供传统方法难以达到甚至无法获得的新型分子结构的途径，（ii）消除许多有毒试剂，使它们变得不必要，（iii）最大限度地减少溶剂的使用，（iv）推广新的我们的提案得到了 21 个涵盖化学使用行业广泛领域的工业合作伙伴的支持，他们提供了 123 万英镑的实物支持。因此，我们将研究广泛的反应，以提供最清楚的了解应用我们技术的有效领域；我们将评估改变基础光物理和动力学的策略，以加速有前景的反应的效率；我们将结合工程、建模和新制造来改变我们当前的光化学和电化学反应器的设计；最大限度地提高效率并提供明确的扩大规模的技术；我们将利用在线分析来加速连续光化学和电化学反应的优化；我们将设计和建造用于新应用的新一代反应器；最将我们的反应器连接到集成的多步骤连续工艺中并最大限度地减少浪费的有效策略；我们将在至少一次大规模的代表性药物目标分子合成中展示这种集成；我们将应用一系列强大的可持续性指标来衡量我们的水平；针对当前制造业的方法。

项目成果

A flow electrochemistry-enabled synthesis of 2-substituted N-(methyl-d)piperidines.

2-取代的 N-(甲基-d)哌啶的流式电化学合成。

• DOI: http://dx.10.1002/jlcr.4006
• 发表时间: 2022
• 期刊: Journal of labelled compounds & radiopharmaceuticals
• 影响因子: 1.8
• 作者: Al

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans.

一种用于合成2-氧代丁-3-烯酰胺和四取代呋喃的环丁烯二酮开环新模式。

• DOI: http://dx.10.1039/d1cc02097h
• 发表时间: 2021
• 期刊: Chemical communications (Cambridge, England)
• 作者: Bennett RM

UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry

UV PhotoVap：演示如何将基于传统旋转蒸发器的简单多功能反应器用于紫外光化学

• DOI: http://dx.10.1021/acs.oprd.8b00037
• 发表时间: 2018
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Clark C

Total synthesis of polymorphatin A, a macrocyclic bisbibenzyl with boat configured arenes

多晶型A（一种具有船型芳烃的大环双联苄）的全合成

• DOI: http://dx.10.1016/j.tet.2020.131521
• 发表时间: 2020
• 期刊: Tetrahedron
• 影响因子: 2.1
• 作者: Almalki F

A systematic study of the interplay between guest molecule structure and intermolecular interactions in crystalline sponges.

结晶海绵中客体分子结构和分子间相互作用之间相互作用的系统研究。

• DOI: http://dx.10.1107/s2052252523005146
• 发表时间: 2023
• 期刊: IUCrJ
• 影响因子: 3.9
• 作者: Carroll RC