Combining laboratory and computational approaches to develop reliable low cost HIV prognostics

结合实验室和计算方法来开发可靠的低成本 HIV 预测

• 批准号: nhmrc : 1112885
• 金额: $ 21.61万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combining-laboratory-computational-hiv-prognostics/663232
• 关键词: Combining; laboratory; computational; approaches; develop

Certain anti-HIV drugs called "CCR5 antagonists" block HIV entry into immune cells. However, HIV drug-resistance can occur. Globally, patient access to CCR5 antagonists has been limited because the pre-treatment laboratory test required to determine HIV drug-resistant is expensive and time-consuming. My research will lead to development of computer programs that reliably, rapidly and cheaply determine HIV drug-resistance and thus greatly improve patient access to CCR5 antagonists worldwide.

某些称为“ CCR5拮抗剂”的抗HIV药物将HIV进入免疫细胞。但是，可能会发生抗HIV药物。在全球范围内，患者进入CCR5拮抗剂的机会受到限制，因为确定耐HIV药物的预处理实验室测试是昂贵且耗时的。我的研究将导致开发计算机程序，这些计划可靠，快速和廉价地确定抗HIV药物的抗药性，从而大大改善患者对全球CCR5拮抗剂的机会。