MARINE METABOLITES FOR BIOMEDICAL RESEARCH

用于生物医学研究的海洋代谢物

• 批准号: 3777871
• 负责人: ABIMAEL D RODRIGUEZ
• 金额: --
• 依托单位: UNIVERSITY OF PUERTO RICO RIO PIEDRAS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3777871
• 关键词: Cnidaria; Invertebrata; Mollusca; Porifera; Tunicata; agriculture; alternatives to animals in research; animal extract; antibacterial agents; antiviral agents; biological products; chemical structure function; chromatography; drug /agent; drug screening /evaluation; field study; neurotoxins; organic chemicals; saltwater environment; spectrometry

Secondary metabolites of marine organisms are our largest untapped source of biologically active organic compounds possessing novel molecular structures. The need is great for discovering new compounds with desirable biological activities which can be used in human therapy as well as in agriculture. Our research group has expertise in the collection, isolation, purification, and structure determination of organic compounds from marine organisms, particularly from invertebrates in the phyla Porifera and Cnideria. We expect to study and make available for screening as therapeutic or agricultural agents 150 marine extracts and new compounds. We will continue our emphasis on sessile animals that lack obvious physical defenses and are thus likely to have evolved chemical survival capability. In addition to sponges, coelenterates, and molluscs, we will explore members of the Bryozoa and Ascidia.

海洋生物的次生代谢物是我们最大的未开发的来源 具有新分子的生物活性有机化合物的 结构。 需求非常适合发现具有理想的新化合物 可以在人类治疗以及中使用的生物活动 农业。 我们的研究小组在收藏方面有专业知识， 有机化合物的隔离，纯化和结构测定 来自海洋生物，特别是从门中的无脊椎动物 porifera和cnideria。 我们希望学习并提供筛查 作为治疗或农业代理人150种海洋提取物和新的 化合物。 我们将继续强调缺乏的无柄动物 明显的身体防御能力，因此很可能已经进化了化学药品 生存能力。 除了海绵，卵形和软体动物外， 我们将探索Bryozoa和Aspidia的成员。