MARINE METABOLITES FOR BIOMEDICAL RESEARCH

用于生物医学研究的海洋代谢物

• 批准号: 3777871
• 负责人: ABIMAEL D RODRIGUEZ
• 金额: --
• 依托单位: UNIVERSITY OF PUERTO RICO RIO PIEDRAS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3777871
• 关键词: Cnidaria; Invertebrata; Mollusca; Porifera; Tunicata; agriculture; alternatives to animals in research; animal extract; antibacterial agents; antiviral agents; biological products; chemical structure function; chromatography; drug /agent; drug screening /evaluation; field study; neurotoxins; organic chemicals; saltwater environment; spectrometry

Secondary metabolites of marine organisms are our largest untapped source of biologically active organic compounds possessing novel molecular structures. The need is great for discovering new compounds with desirable biological activities which can be used in human therapy as well as in agriculture. Our research group has expertise in the collection, isolation, purification, and structure determination of organic compounds from marine organisms, particularly from invertebrates in the phyla Porifera and Cnideria. We expect to study and make available for screening as therapeutic or agricultural agents 150 marine extracts and new compounds. We will continue our emphasis on sessile animals that lack obvious physical defenses and are thus likely to have evolved chemical survival capability. In addition to sponges, coelenterates, and molluscs, we will explore members of the Bryozoa and Ascidia.

海洋生物的次生代谢物是我们最大的未开发来源 具有新颖分子结构的生物活性有机化合物 结构。 非常需要发现具有理想性能的新化合物 生物活性可用于人类治疗以及 农业。 我们的研究小组在收藏方面拥有专业知识， 有机化合物的分离、纯化和结构测定 来自海洋生物，特别是来自无脊椎动物门 多孔动物门和刺胞动物门。 我们希望进行研究并可供筛选 作为治疗剂或农业剂 150 种海洋提取物和新 化合物。 我们将继续重点关注缺乏 明显的物理防御，因此很可能进化出化学防御 生存能力。 除了海绵、腔肠动物和软体动物之外， 我们将探索苔藓虫纲和海鞘纲的成员。