BIOACTIVE SECONDARY METABOLITES FROM MARINE INVERTEBRATES

海洋无脊椎动物的生物活性次级代谢产物

• 批准号: 3778434
• 负责人: BULENT TEREM
• 金额: --
• 依托单位: CHAMINADE UNIVERSITY OF HONOLULU
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3778434
• 关键词: Cnidaria; Invertebrata; Mollusca; Porifera; Rotifera; antimetabolites; bioassay; biological products; chemical structure function; chemical synthesis; cyclization; drug design /synthesis /production; high performance liquid chromatography; marine biology; nuclear magnetic resonance spectroscopy; physical separation; thin layer chromatography

The proposed project is an investigative study of bioactive secondary metabolites in Hawaiian marine invertebrates mainly those belonging to phyla Porifera, Mollusca, Cnideria, and Bryozoa. The selection of the organisms is planned on ecological grounds. Isolation work will follow collection with bioactivity tests being performed at various stages of the separation process. Chemical studies initiated on the already isolated sponge metabolite ilimaquinone will continue, focusing on the elucidation of the rearrangement and cyclization reactions undergone by the molecule. Based on this chemistry, a new synthetic of related compounds. Avarol, which is reported to be active against the AIDS virus, is structurally very similar to ilimaquinone, both possessing a rearranged drimane skeleton linked to a quinone moiety. Student participation at each stage of this project is proposed with an emphasis on creative thinking, development of experimental skills, and more importantly, increased motivation towards a career in biomedical sciences.

拟议的项目是对生物活性次级的调查研究 夏威夷海洋无脊椎动物的代谢产物主要是 门porifera，Mollusca，Cnideria和Bryozoa。 选择 有机体是基于生态学的。 隔离工作将随后 在各个阶段进行生物活性测试的收集 分离过程。 化学研究是在已经孤立的 海绵代谢产物Ilimaquinone将继续进行，重点是阐明 分子的重排和环化反应经历了。 基于这种化学，是相关化合物的新合成。 avarol， 据报道，它针对艾滋病病毒具有活性，在结构上非常非常 类似于Ilimaquinone，都有重排的Dr​​imane骨架 链接到醌部分。 学生在每个阶段的参与 提出了项目，重点是创造性思维，发展 实验技能，更重要的是，增加了一个动力 生物医学科学的职业。