MULTICHANNEL UNIVERSAL BIOPOLYMER PURIFICATION SYSTEM

多通道通用生物聚合物纯化系统

• 批准号: 3503458
• 负责人: MARCIA E HANSEN
• 金额: $ 5万
• 依托单位: FFFRACTIONATION, LLC
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3503458
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; fluid flow; fluorescent dye /probe; fluorimetry; hydropathy; mechanical pressure; membrane; microcapsule; molecular size; molecular weight; physical chemical interaction; physical separation; polymers; polystyrenes; slow release drug; surface property; tensile strength

Flow Field-Flow Fractionation has recently been demonstrated as a high speed analytical tool for separation and characterization of biopolymers and cell particles in the size range of 0.01 to 50 microns (1,2). Extension and commercialization of this technology for preparative scale applications is proposed. The use of an array of channels in a Flow FFF system offers potential for the development of a rapid universal biopolymer purification system for preparative scale fractionation of biopolymers of wide molecular weight/size distribution. Specifically, the multichannel design involves the use of membranes with decreasing pore sizes in a stacked assembly. The proposed Phase I focusses on membrane technology and the feasibility of commercialization of this multichannel universal biopolymer purification system.

流场 - 流分馏最近已被证明为高 分离和表征生物聚合物的速度分析工具 尺寸范围为0.01至50微米的细胞颗粒（1,2）。 该技术的扩展和商业化用于制备量表 提出了申请。 流量FFF系统中的一系列通道的使用为 开发快速通用的生物聚合物纯化系统 宽分子的生物聚合物的制备量表分级 重量/尺寸分布。 具体而言，多通道设计涉及 在堆叠组件中使用孔尺寸降低的膜的使用。 这 提议的第一阶段重点关注膜技术和可行性 该多通道通用生物聚合物纯化的商业化 系统。