NEW GENERATION PATHOLOGISTS' MICROSCOPE

新一代病理学家显微镜

• 批准号: 3498486
• 负责人: KENDALL PRESTON
• 金额: $ 5万
• 依托单位: KENSAL CORPORATION
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-12 至 1992-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498486
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; digital imaging; fiber optics; histopathology; microscopy; optics; personal computers; sectioning

This proposal is submitted to NIGMS in connection with the expressed interest of that institution in microscopic instrumentation techniques related to the engineering and physical sciences under the Biophysics and Physiological Sciences Program. The submitting organization is Kensal Consulting, a small electrooptical business in Tucson, Arizona, that has invented and patented what is felt to be the next generation pathologists' microscope. This new microscope will bring full-color digital visualization of tissue sections to the desktop and provide the pathologist with a "PC-Microscope" that is likely to supplant traditional microscopy. The traditional microscope does not furnish full-coverslip imaging; nor does it provide orientation information; nor can it be used to continuously zoom. Kensal's PC-Microscope, using a novel linear-diode-array slide scanner, will bring a full-color, full- coverslip image to the computer screen 1 or 2 seconds after insertion of the microscope slide in the instrument. Thereafter the user will select regions of interest from the screen by pointing at the coverslip image with a cursor. These regions will appear at high magnification and can be panned, focused, and zoomed continuously using a novel CFM (Continuously Focusing Microscope) recently patented by Infinity Photo- Optical Company. No oculars will be necessary, no manual handling of the slide and stage; no manual switching of fixed-power objectives as in traditional microscopy. The purpose of this proposal is to request SBIR funding to demonstrate the feasibility of fast full-coverslip imaging and to study the combination of this imaging modality with a complete, digitally-controlled, electrooptical mechanism that will be implemented as a PC-Microscope prototype in Phase II and commercialized during Phase III.

该提案与表达的有关 该机构对微观仪器技术的兴趣 与生物物理学下的工程和物理科学有关 和生理科学计划。 提交的组织是 肯萨尔咨询公司（Kensal Consulting），亚利桑那州图森的一家小型电动业务 这已经发明和申请了下一代的专利 病理学家的显微镜。 这个新的显微镜将带来全色 将组织部分的数字可视化到桌面，并提供 病理学家具有“ PC微镜”，可能取代 传统显微镜。 传统显微镜不提供 全覆盖成像；它也不提供方向信息；也不 可以用来连续变焦吗？ Kensal的PC-Microscope，使用 新颖的Linear-Diode-Array幻灯片扫描仪，将带来全彩的全彩色 插入后1或2秒钟的计算机屏幕覆盖图像 显微镜在仪器中滑动。 此后，用户将选择 屏幕上关注的区域通过指向盖玻片图像 与光标。 这些区域将出现高放大倍数，可以 使用新颖的CFM持续插入，集中和缩放 （连续聚焦显微镜）最近获得了Infinity Photo- 光学公司。 无需眼镜，没有手动处理 幻灯片和舞台；没有像在 传统显微镜。 该建议的目的是要求SBIR 资金以证明快速全卷饼成像的可行性 并研究这种成像方式与完整的， 将实施的数字控制，电流机制 作为II期的PC微镜原型，并在阶段进行商业化 iii。