IMAGE HANDLING SYSTEM FOR PATHOLOGY AND TELEPATHOLOGY

病理学和远程病理学图像处理系统

• 批准号: 2182513
• 负责人: KENDALL PRESTON
• 金额: $ 24.23万
• 依托单位: KENSAL CORPORATION
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-12 至 1997-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2182513
• 关键词: cellular pathology; computer system design /evaluation; digital imaging; fiber optic microscopy; human tissue; image processing; online computer; personal computers; telecommunications; television; video microscopy

Surgical pathology is, approximately, a 20 billion dollar a year industry (USA only). Unlike cyto- and hemapathology that focus on microscopic cells, surgical pathology is concerned with large tissue sections. Tissue sections are mounted under a coverslip on standard 3x1 inch microscope slides of which from 50 to 100 million are prepared per year. For at least ten years the PI (Principal Investigator) has worked with surgical pathologists interested in digital image handling. Again and again they have emphasized the diagnostic importance of scanning tissue sections at the lowest magnification possible. Yet, physical optics absolutely prevents any microscope lens from imaging the entire 50X25 mm coverslip. To solve this problem, the PI invented and received a patent on (1988) an entirely new instrument called PCM (PC Microscope) that, using a semiconductor-diode, fiber-optic device would permit a FCS (full coverslip) scan employing "shadow imaging." In addition, PCM would provide real-time, high-magnification display of regions selected from the shadow image with submicron resolution. Phase I NIH SBIR funding was requested to study the feasibility of PCM. When FCS images were shown to surgical pathologists, the comments were "fantastic" [University of Southern California], "remarkable and magnificent" [Mayo Clinic], etc. The president of the Association of Pathology Chairmen, i.e., the top pathologists in the USA, stated that he envisaged a market of 50,000 units. In diametric opposition to these comments by our potential customers and for reasons that the PI finds incomprehensible, the two NIH Study Sections that reviewed our request for Phase II SBIR funding stated that PCM was only a "laboratory curiosity" with a "very limited, perhaps non-existent [market]." The PI, therefore, is again requesting Phase II SBIR funding to reduce PCM to practice and then use two or more PCMs in a network demonstration (telepathology) where FCS is essential. PROPOSED COMMERCIAL APPLICATION: Optical microscopy is used by thousands of surgical pathologists in the USA and further thousands worldwide. No microscope today can provide simultaneous images of the entire coverslip as well as high resolution images of selected portions thereof. KSC's new microscope system provides both fast full coverslip imaging as well as real-time HDTV in a single low-cost unit. KSC's system is seen as the next generation microscope for surgical pathology. The chairman of the largest pathology department in the USA estimates a market of 50,000 units.

手术病理大约是每年200亿美元的行业 （仅美国）。与关注显微镜的细胞和偏瘫不同 细胞，手术病理与大组织切片有关。组织 部分安装在标准3x1英寸显微镜的盖玻片下 每年准备50万至1亿张幻灯片。至少 十年PI（首席研究员）已与外科手术合作 对数字图像处理感兴趣的病理学家。他们一次又一次 强调了扫描组织切片的诊断重要性 最低放大倍数。但是，物理光学器件绝对 防止任何显微镜镜头对整个50x25 mm进行成像 盖玻片。为了解决这个问题，PI发明并获得了专利 （1988）一种称为PCM（PC显微镜）的全新仪器 使用半导体二极管，光纤设备将允许FCS（满 盖玻片）扫描采用“阴影成像”。此外，PCM会 提供实时的高磁化显示，从 带有亚微米分辨率的阴影图像。 I阶段NIH SBIR资金是 要求研究PCM的可行性。当显示FCS图像时 对于外科病理学家来说，评论是“很棒的” [大学 南加州]，“杰出而宏伟的” [梅奥诊所]，等。 病理学协会主席主席，即顶级 美国的病理学家说，他设想了50,000的市场 单位。我们的潜力反对这些评论的对立 客户以及Pi认为难以理解的原因，两者 NIH研究部分审查了我们对II阶段SBIR资金的要求 指出PCM只是“实验室好奇心”，“非常有限， 也许不存在[市场]。 第二阶段SBIR资金以减少PCM进行练习，然后使用两个或 网络演示中的更多PCM（远程病理学），其中FCS是 基本的。 拟议的商业应用： 光学显微镜在数千名外科病理学家中使用 美国和全球成千上万。今天没有显微镜可以提供 整个盖玻片以及高分辨率的同时图像 选定部分的图像。 KSC的新显微镜系统 在A中提供快速全盖玻片成像以及实时HDTV 单个低成本单元。 KSC的系统被视为下一代 手术病理学显微镜。最大病理主席 美国部门估计市场为50,000个单位。