FACTORS AFFECTING DISTRIBUTION OF MYOCARDIAL FLOW

影响心肌血流分布的因素

• 批准号: 3485565
• 负责人: JOSEPH C GREENFIELD
• 金额: $ 17.4万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3485565
• 关键词: adenosine; atrial fibrillation; cardiac output; cardiovascular stress test; collateral circulation; coronary occlusion /thrombosis; coronary vasodilator; dogs; heart circulation; heart pharmacology; intracardiac pressure; isoproterenol; methoxamine; myocardial ischemia /hypoxia; nitroglycerin; oxygen consumption; purine /pyrimidine metabolism; reactive hyperemia; swine; tachycardia; vascular resistance; ventricular hypertrophy

The proposed research will continue to elucidate the multiple factors which control myocardial perfusion. As in the past, the aim of this work is to answer questions important in defining the physiology and pathophysiology of coronary blood flow in animal models which are closely akin to man in a physiologic state. Thus, this work will be carried out in awake animal models. The research proposal contains two specific aims: 1) beat-to-beat regulation of coronary blood flow, and 2) physical, pharmacologic and neural factors which affect atrial blood flow.

拟议的研究将继续阐明多种因素 控制心肌灌注。 就像过去一样，这项工作的目的是 回答问题对于定义生理和病理生理学重要 动物模型中的冠状动脉流动，与男人相似 生理状态。 因此，这项工作将在清醒的动物中进行 型号。 研究建议包含两个具体的目的：1） 调节冠状动脉流动，2）物理，药理和 影响心房血流的神经因素。