FACTORS AFFECTING DISTRIBUTION OF MYOCARDIUM FLOW

影响心肌血流分布的因素

• 批准号: 3335593
• 负责人: JOSEPH C GREENFIELD
• 金额: $ 24.84万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1986-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3335593
• 关键词: adenosine; artery stenosis; cardiovascular stress test; collateral circulation; coronary artery; coronary occlusion /thrombosis; coronary vasodilator; disease /disorder model; electronic pacemaker; endocardium; heart circulation; heart dimension /size; heart imaging /visualization /scanning; heart pharmacology; hypertension; intracardiac pressure; isoproterenol; methoxamine; myocardium; nitroglycerin; purine /pyrimidine metabolism; reactive hyperemia; tachycardia; ventricular hypertrophy

This proposal is to continue studies designed to elucidate the multiple factors which control myocardial perfusion and function. Although the work will not be carried out in human subjects, each of the proposed studies is designed to answer questions of importance in defining the physiology or pathophysiology of cardiac function in man during health and disease. To this end, whenever possible, studies are carried out in awake animals; animal models simulating human cardiovascular disease are employed. The research proposal contains six general categories: 1. Response of coronary vasculature to brief perturbations. 2. Interaction between myocardial blood flow and mechanical properties of the left ventricle. 3. The role of purine metabolism in determining myocardial function following brief ischemia. 4. Collateral development and function in dogs and pigs. 5. Myocardial blood flow in the hypertrophied ventricle. 6. Myocardial mechanics in the hypertrophied ventricle.

该建议是继续旨在阐明多种因素的研究 哪个控制心肌灌注和功能。 虽然这项工作不会 在人类受试者中进行的每个研究都设计为 回答定义生理或病理生理学的重要性问题 健康和疾病期间人类的心脏功能。 为此，每当 可能在清醒的动物中进行研究。动物模型模拟 采用人类心血管疾病。 研究建议包含六个 一般类别：1。冠状动脉血管对短暂扰动的反应。 2。心肌流动与机械性能之间的相互作用 左心室。 3。嘌呤代谢在确定心肌中的作用 功能以下简短的缺血。 4。附带的发展和功能 狗和猪。 5。肥厚的心室中心肌血流。 6。 肥厚性心室中的心肌力学。