FACTORS AFFECTING DISTRIBUTION OF MYOCARDIAL FLOW

影响心肌血流分布的因素

• 批准号: 3485564
• 负责人: JOSEPH C GREENFIELD
• 金额: $ 19.86万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-05-01 至 1991-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3485564
• 关键词: adenosine; atrial fibrillation; cardiac output; cardiovascular stress test; collateral circulation; coronary occlusion /thrombosis; coronary vasodilator; dogs; heart circulation; heart pharmacology; intracardiac pressure; isoproterenol; methoxamine; myocardial ischemia /hypoxia; nitroglycerin; oxygen consumption; purine /pyrimidine metabolism; reactive hyperemia; swine; tachycardia; vascular resistance; ventricular hypertrophy

The proposed research will continue to elucidate the multiple factors which control myocardial perfusion. As in the past, the aim of this work is to answer questions important in defining the physiology and pathophysiology of coronary blood flow in animal models which are closely akin to man in a physiologic state. Thus, this work will be carried out in awake animal models. The research proposal contains two specific aims: 1) beat-to-beat regulation of coronary blood flow, and 2) physical, pharmacologic and neural factors which affect atrial blood flow.

拟议的研究将继续阐明影响因素 控制心肌灌注。 与过去一样，这项工作的目的是 回答定义生理学和病理生理学的重要问题 与人类非常相似的动物模型中的冠状动脉血流量 生理状态。 因此，这项工作将在清醒的动物中进行 模型。 该研究提案包含两个具体目标：1）逐个节拍 冠状动脉血流的调节，以及 2) 物理、药理和 影响心房血流的神经因素。