POSITRON PROBE FOR CORNEAL TUMOR BIOASSAY

用于角膜肿瘤生物测定的正电子探针

• 批准号: 3492010
• 负责人: GERALD ENTINE
• 金额: $ 5万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1990-04-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3492010
• 关键词: bioassay; clinical biomedical equipment; cornea; drug screening /evaluation; gamma radiation; glioma; high energy particle; human therapy evaluation; implant; neoplasm /cancer chemotherapy; particle accelerators; phantom model; positron emission tomography; radiation detector; radiotracer

Recently, preliminary research using cyclotron produced, positron emitting radiolabels has been conducted at the Memorial Sloan Kettering Cancer Center to develop a rabbit/rat corneal implant method to study human tumor angiogenesis and metabolism. This technique is designed to determine the impact of chemotherapeutic strategies directly on human brain tumors and provides the hope that drug screening for patients with gliomas can be carried out with sufficient efficacy that a substantial increase in the long term survival rate of such patients can be achieved. To develop such a protocol, unique equipment is needed to measure the accumulation of positron labeled amino acids within the tumor with high sensitivity and spacial resolution despite the presence of an extremely large background from the associated 511 key gamma rays. We propose a program to develop a small, solid state, dual element positron-gamma probe specifically designed for use with the positron emitting isotopes central to the development of this bioassay. Such a low cost, non-imaging system which will allow high quality measurements of metabolic indices for basic and applied medical research will be a useful addition to the capabilities of medical cyclotron groups.

最近，利用回旋加速器产生的正电子发射进行了初步研究 放射性标记已在纪念斯隆凯特琳癌症中心进行 中心开发兔/大鼠角膜植入方法来研究人类肿瘤 血管生成和代谢。该技术旨在确定 化疗策略对人类脑肿瘤的直接影响 为神经胶质瘤患者的药物筛查提供了希望 并以足够的效率进行，使 此类患者可以获得长期生存率。 为了开发这样的协议，需要独特的设备来测量 正电子标记氨基酸在肿瘤内的积累 尽管存在极端的灵敏度和空间分辨率 来自相关 511 个关键伽马射线的大背景。 我们提出了一个开发小型固态双元件的计划 专为与正电子一起使用而设计的正电子伽马探针 发射对这种生物测定的发展至关重要的同位素。这么低 成本，非成像系统，将允许高质量的测量 基础和应用医学研究的代谢指数将是一个有用的 除了医疗回旋加速器组的功能之外。