P30 - CENTER CORE GRANT FOR VISION RESEARCH

P30 - 愿景研究中心核心拨款

• 批准号: 8339590
• 负责人: LINDA M ZANGWILL
• 金额: $ 72.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8339590
• 关键词: Address; Algorithms; Anatomy; Animal Model; Animal Structures; Animal Technicians; Animals; Applications Grants; Appointment; Area; Basic Science; Bioinformatics; Biological; Biological Markers; Biology; Biomedical Engineering; Biometry; Blood Vessels; California; Cancer Center Support Grant; Cellular biology; Center Core Grants; Clinical Research; Collaborations; Communities; Complex; Computational Science; Computer Analysis; Computers; Confocal Microscopy; Cornea; Data; Data Set; Descriptor; Development; Diabetic Retinopathy; Educational process of instructing; Electrophysiology (science); Engineering; Ensure; Environment; Epidemiology; Equipment; Eye; Eye diseases; Faculty; Family Practice; Fostering; Foundations; Functional Imaging; Funding; Future; Genetic; Genomics; Glaucoma; Goals; Health Sciences; High Performance Computing; Histology; Housing; Human; Human Resources; Image; Image Analysis; Immunohistochemistry; Individual; Information Technology; Institutes; Interdisciplinary Study; Laboratories; Laboratory Animals; Letters; Libraries; Life; Macular degeneration; Mathematics; Measurement; Medical; Medical Records; Medicine; Metadata; Methodology; Methods; Microscope; Molecular Biology; Neurosciences; Noise; Online Systems; Ophthalmology; Pathology; Pediatrics; Pharmacologic Substance; Prevention; Preventive Medicine; Process; Productivity; Psychology; Radiology Specialty; Reagent; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Retina; Retinal; Retinal Degeneration; Science; Scientist; Secure; Services; Statistical Models; Techniques; Telecommunications; Testing; Time; Tissues; Training; Travel; United States National Institutes of Health; Universities; Vision; Vision research; Work; animal care; animal facility; computer program; computer science; computing resources; cost; digital; eye center; fluorescence imaging; health science research; image processing; imaging modality; improved; innovation; insight; instrument; investigator training; light microscopy; meetings; professor; programs; ranpirnase; research study; restoration; square foot; supercomputer; tissue processing; tool

DESCRIPTION (provided by applicant): This University of California, San Diego (UCSD) Vision Research Core grant proposal will provide critical resources in 4 distinct substantive areas to leverage the expertise of NEI funded UCSD investigators and to accelerate discoveries from their NIH funded studies. 15 investigators have a total of 18 NEI funded eligible R01 projects. These investigators from the UCSD Departments of Ophthalmology, Pathology, Pediatrics, Institute for Genomic Medicine, Radiology, and Psychology represent an impressive, productive, and a collegial group of vision researchers. UCSD vision researchers encompass all levels of faculty appointments and research accomplishments, from 9 full professors who are leaders in their respective fields to 6 recently recruited junior faculty (Drs. Annese, Balasubramanian, Bosworth, Huberman, Ju, Lin). Moreover, the substantial funding from other NIH institutes and foundations (Table 2) further highlights the strength of UCSD's vision research program. In particular, our portfolio is strong in human and animal imaging and functional assessment, image analysis, epidemiology/clinical research, genetics, glaucoma, AMD, retinal degeneration, cell biology, molecular biology, animal models, and vascular biology. The UCSD Department of Ophthalmology has a long tradition of excellence in glaucoma and retina research. With the recent recruitment of seven additional NEI funded investigators (Drs. Ayyagari, La Spada, Lin, Ju, Zhang, and most recently Balasubramanian and Huberman), vision research at UCSD has reached a critical mass that will benefit from an infrastructure to coordinate, enhance and leverage the expertise of each participating investigator to benefit the entire UCSD vision research community. Currently, 9 NEI funded investigators have offices and laboratories in the adjacent and interconnected Shiley Eye Center (SEC), Hamilton Glaucoma Center (HGC) and Jacobs Retina Center (HRC). The two adjoining research centers (Hamilton Glaucoma Center and Jacobs Retina Center) comprise 26,000 sq ft of dedicated research and office space. The SEC also provides extensive computer/IT support, and independent medical record services, as well as houses an auditorium and library. Another 6 NEI-funded investigators have offices nearby (less than a 5 minute drive from the Dept of Ophthalmology) at the main UCSD campus and adjoining Health Sciences research complex. The main campus includes vision researchers from the Depts. of Psychology (Dr. MacLeod), Biology(Dr. Rainegel), Neuroscience (Dr. Huberman) and Bioengineering (Dr. Silva). The Health Sciences complex includes the Institute for Genomic Medicine, Skaggs Pharmaceutical Sciences Building (Drs. Zhang and La Spada), the Division of Biostatistics and Bioinformatics and Biostatistics Research Center (BRC) in the Department of Family and Preventive Medicine (Dr. Jain) and the Basic Science Building-BSB with adjoining Medical Teaching Facility-MTF which house the animal care facilities and animal laboratories of Drs. Lin, Ju, Freeman, Bartsch, and Weinreb. Moreover, the UCSD Vision Research Core will leverage the unique engineering and computational expertise of UCSD's Center for Computational Sciences, Mathematics, and Engineering¿CSME training initiative. Computer Science (Prof David Kriegman) and Math Department (Prof Michael Hoist - see letter of support), the California Institute of Telecommunications and Information Technology (CALIT2- whose mandate is to enhance the "collaborative research environment for the digital future" for details see http://www.calit2.net/) (Prof Larry Smarr- see letter of support), and the resources of the San Diego Supercomputer Center to enhance current research endeavors and extend existing collaborations (e.g., Glaucoma-Math-Calit2 collaboration) to the broader vision research community. The overall purpose of this application is to provide shared resources to enhance and accelerate the productivity of the vision research community at UCSD. The following 4 modules will provide important new resources and services that are currently unavailable or difficult for each investigator to obtain individually. Each module has either 2 Co-Directors (each with NEI ROI funding), or a Director and Assistant Director (with specific expertise valuable to the module) to ensure administrative coverage so that issues can be addressed in a timely manner regardless of travel or other commitments by one of the Directors. In addition, the personnel for each module will both provide direct services (e.g. statistical analyses, computer programming, histology) and also train investigators and their staff to complete tasks so that module resources are utilized as efficiently as possible for maximum productivity. PUBLIC HEALTH RELEVANCE: The UCSD Vision Research Core will provide the most advanced and innovative methods as shared resources to foster collaboration and to bring us closer to our goal of the prevention and cure of blinding eye diseases such as glaucoma, macular degeneration, and diabetic retinopathy.

描述（由适用提供）：这位加利福尼亚大学圣地亚哥分校（UCSD）Vision Research Research赠款提案将在4个不同的实质领域提供关键的资源，以利用NEI资助的UCSD研究人员的专业知识，并从其NIH资助的研究中加速发现。 15名调查人员共有18个NEI资助的合格R01项目。来自UCSD眼科，病理学，儿科，基因组医学，放射学和心理学研究所的研究人员代表着令人印象深刻的，产品和一群视觉研究人员。 UCSD视觉研究人员涵盖了所有级别的教师任命和研究成就，来自9位全体领导者的全部教授到最近有6名最近招募的初级教师（Annese博士，Balasubramanian，Bosworth，Bosworth，Bosworth，Bosworth，Huberman，Huberman，JU，JU）。此外，其他NIH机构和基金会的大量资金（表2）进一步凸显了UCSD视觉研究计划的实力。特别是，我们的投资组合在人类和动物成像和功能评估，图像分析，流行病学/临床研究，遗传学，青光眼，AMD，残留变性，细胞生物学，分子生物学，动物模型和血管生物学方面都很强大。 UCSD眼科系在青光眼和视网膜研究方面具有悠久的卓越传统。随着最近招募另外七名NEI资助的研究人员（Ayyagari博士，La Spada，Lin，Ju，Zhang，以及最近的Balasubramanian和Huberman），UCSD的视觉研究达到了一个关键质量，该批量研究将受益于从基础设施中受益，以协调和驱动每个参与研究师的专业研究，从而使整个UC的专业研究受益于整个UC的专业研究。目前，有9名NEI资助的研究人员在相邻且相互联系的Shiley Eye Center（SEC），汉密尔顿青光眼中心（HGC）和Jacobs Retina Center（HRC）设有办事处和实验室。两个毗邻的研究中心（汉密尔顿青光眼中心和雅各布斯视网膜中心）组成了26,000平方英尺的专用研究和办公空间。 SEC还提供广泛的计算机/IT支持以及独立的病历服务，并设有礼堂和图书馆。另外6名NEI资助的调查人员在UCSD主要校园和毗邻的健康科学研究所附近设有办事处（距离眼科部门不到5分钟车程）。主要校园包括来自部门的视觉研究人员。心理学（麦克劳德博士），生物学（Rainegel博士），神经科学（Huberman博士）和生物工程（Silva博士）。健康科学综合体包括基因组医学研究所，Skaggs药学大楼（Zhang博士和La Spada博士），家庭与预防医学部（JAIN博士）的生物统计学和生物信息学和生物统计学研究中心（BRC），以及基础科学大楼，由动物医疗机构进行辅助医疗机构和辅助工具，该部门的医疗机构及其动物医疗机构。林，JU，Freeman，Bartsch和Weinreb。此外，UCSD视觉研究核心将利用UCSD计算科学，数学和工程学中心的独特工程和计算专业知识。 Computer Science (Prof David Kriegman) and Math Department (Prof Michael Hoist - see letter of support), the California Institute of Telecommunications and Information Technology (CALIT2- whose mandate is to enhance the "collaborative research environment for the digital future" for details see http://www.calit2.net/) (Prof Larry Smarr- see letter of support), and the resources of the San Diego Supercomputer Center to enhance current research努力并将现有的合作（例如青光眼 - 钙化2合作）扩展到更广泛的视力研究社区。该应用程序的总体目的是提供共享的资源，以增强和加快UCSD视觉研究社区的生产率。以下4个模块将提供重要的新资源和服务，目前每个调查员都无法单独获取。每个模块都有2个共同导演（每个模块都有NEI ROI资金），或一个董事和助理董事（对模块具有特定的专业知识价值），以确保行政覆盖范围，以便无论旅行如何，都可以及时解决问题。此外，每个模块的人员都将提供直接服务（例如统计分析，计算机编程，组织学），还将培训调查人员及其员工完成任务，以便尽可能有效地利用模块资源来提高生产率。 公共卫生相关性：UCSD视觉研究核心将提供最先进和创新的方法作为共享资源，以促进协作，并使我们更接近预防和治愈盲目的眼病的目标，例如青光眼，黄斑变性，糖尿病性视网膜。