NEI Center Core Grant for Vision Research

NEI 中心视觉研究核心资助

• 批准号: 10709400
• 负责人: LINDA M ZANGWILL
• 金额: $ 61.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709400
• 关键词: Acceleration; Address; Anatomy; Animal Structures; Animals; Award; Basic Science; Biology; Biometry; Biostatistics Core; California; Center Core Grants; Clinical; Clinical Research; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communities; Computer software; Computers; Core Grant; Data; Data Science; Database Management Systems; Dedications; Dependovirus; Diabetic Retinopathy; Drug Screening; Electronic Health Record; Eligibility Determination; Engineering; Ensure; Equipment; Eye; Eye diseases; Faculty; Family; Fostering; Functional Imaging; Funding; Future; Genes; Genomic medicine; Glaucoma; Goals; Health; Histology; Human; Human Resources; Image; Immunohistochemistry; Individual; Informatics; Infrastructure; Institution; Interdisciplinary Study; Lentivirus Vector; Licensing; Macular degeneration; Microscopy; Names; National Eye Institute; Neurosciences; Ophthalmology; Performance; Pharmacology; Prevention; Process; Production; Productivity; Psychology; Research; Research Personnel; Resource Sharing; Resources; Schools; Scientist; Secure; Services; Techniques; Tissues; United States National Institutes of Health; Universities; Viral; Vision; Vision research; biomedical imaging; biomedical informatics; cloud based; computer science; computing resources; dimensional analysis; high dimensionality; histological specimens; improved; instrumentation; programs; research study; service organization; structural imaging; tissue processing; Acceleration; Address; Anatomy; Animal Structures; Animals; Award; Basic Science; Biology; Biometry; Biostatistics Core; California; Center Core Grants; Clinical; Clinical Research; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communities; Computer software; Computers; Core Grant; Data; Data Science; Database Management Systems; Dedications; Dependovirus; Diabetic Retinopathy; Drug Screening; Electronic Health Record; Eligibility Determination; Engineering; Ensure; Equipment; Eye; Eye diseases; Faculty; Family; Fostering; Functional Imaging; Funding; Future; Genes; Genomic medicine; Glaucoma; Goals; Health; Histology; Human; Human Resources; Image; Immunohistochemistry; Individual; Informatics; Infrastructure; Institution; Interdisciplinary Study; Lentivirus Vector; Licensing; Macular degeneration; Microscopy; Names; National Eye Institute; Neurosciences; Ophthalmology; Performance; Pharmacology; Prevention; Process; Production; Productivity; Psychology; Research; Research Personnel; Resource Sharing; Resources; Schools; Scientist; Secure; Services; Techniques; Tissues; United States National Institutes of Health; Universities; Viral; Vision; Vision research; biomedical imaging; biomedical informatics; cloud based; computer science; computing resources; dimensional analysis; high dimensionality; histological specimens; improved; instrumentation; programs; research study; service organization; structural imaging; tissue processing

SUMMARY Overall The overall purpose of the Center Core Grant for Vision Research is to provide core services and resources to enhance and accelerate the productivity and impact of the vision research community at the University of California, San Diego. Specifically, the Center Core Grant for Vision Research will leverage the outstanding basic science and clinical research expertise of National Eye Institute funded investigators by providing important resources and services organized into the following five distinct cores. 1. The Vision Biostatistics Core provides dedicated statistical expertise for the vision research community at UCSD. There are several common analysis themes and statistical issues that can be addressed effectively and efficiently by having a dedicated biostatistician familiar with eye research to analyze vision-related data and to ensure rigor and transparency of the results. 2. The Animal Structure and Function Core will provide shared instrumentation and a technician to assist with ocular structural imaging and functional imaging in animals. 3. The Computational Ophthalmology and Biomedical Informatics Core provides i) dedicated high- performance CPU and GPU computing resources ii) 3 computer programmers, iii) institutional software licenses, iv) electronic health record data extraction services, v) cloud-based data management infrastructure, and vi) secure file sharing and backup services to support UCSD’s cellular, animal and human vision research studies. 4. The Histology, Tissue Processing and High Content Microscopy Core provides rapid characterization of eye tissue with respect to histology, immunohistochemistry and high content microscopy for drug screening and histologic specimen imaging by supporting instrumentation and a technician who is familiar with ocular anatomy and techniques required to properly process ocular tissues. 5. The new Viral Production and CRISPR Engineering Core provides centralized dedicated space, equipment and personnel for the production, isolation and titering of adeno-associated virus (AAV) and lentivirus (LV) vectors and assistance with non-viral CRISPR gene editing. These cores will improve the efficiency and productivity and impact of UCSD vision scientists by providing core services that are unavailable or not easily accessible to individual investigators. The core grant infrastructure and resources also leverage the expertise of each participating investigator to enhance multidisciplinary collaboration for the benefit of the entire UCSD vision research community.

概括 全面的 视觉研究中心核心赠款的总体目的是提供核心服务和资源 提高和加速大学愿景研究界的生产力和影响 加利福尼亚，圣地亚哥。具体而言，视觉研究的中心核心赠款将利用出色的 国家眼科研究所的基础科学和临床研究专业知识通过提供 重要的资源和服务组织到以下五个不同的核心中。 1。视觉生物统计学核心为视觉研究社区提供专门的统计专业知识 UCSD。有几个常见的分析主题和统计问题可以有效地解决 通过让专门的生物统计学家熟悉眼睛研究来分析与视力相关的数据，并有效地有效 并确保结果的严格和透明度。 2。动物结构和功能核心将提供共享的仪器和技术人员来协助 与动物中的眼结构成像和功能成像。 3。计算眼科和生物医学信息学核心提供的i）专用高级 绩效CPU和GPU计算资源ii）3计算机程序员，iii）机构软件 许可，iv）电子健康记录数据提取服务，v）基于云的数据管理 基础架构和vi）安全文件共享和备份服务，以支持UCSD的蜂窝，动物和 人类视觉研究。 4。组织学，组织加工和高含量显微镜核心提供了快速表征 关于组织学，免疫组织化学和高含量显微镜的眼组织，用于药物筛查 和组织学标本成像，通过支持仪器和熟悉眼的技术人员 解剖学和正确处理眼组织所需的技术。 5。新的病毒生产和CRISPR工程核心提供集中的专用空间， 与腺相关病毒（AAV）和生产，隔离和作生产的设备和人员 慢病毒（LV）载体和非病毒CRISPR基因编辑的帮助。 这些核心将通过提供UCSD愿景科学家的效率和生产率和影响 单个调查人员无法获得或不容易访问的核心服务。核心赠款 基础架构和资源还利用每个参与调查员的专业知识来增强 多学科合作，为整个UCSD视觉研究社区的利益。