SENSORIMOTOR INTEGRATION IN POSTERIOR CINGULATE CORTEX

后扣带皮层的感觉运动整合

• 批准号: 3413517
• 负责人: Carl Roger Olson
• 金额: $ 12.35万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3413517
• 关键词: Macaca mulatta; attention; brain electrical activity; cingulate gyrus; memory; neural information processing; saccades; sensorimotor system; visual stimulus

DESCRIPTION (Adapted from applicant's abstract): Four series of experiments are proposed. 1) Preliminary data indicate that posterior cingulate neurons encode orbital position, saccade direction and amplitude, and respond to visual stimuli. The first series of experiments is designed to characterize more fully the eye movement related activity and visual responsiveness of posterior cingulate neurons. The monkey will perform a series of tasks to identify relationships to orbital position, direction, and amplitude in the optimal target direction. Dependence on visual feedback will be tested by examining discharge with saccades in the dark. Next (exp 1c) visual response properties will be characterized, in which size, brightness and direction of motion of targets (checkerboards) will be varied. In experiment 1d. the effect of orbital position on visual responsiveness will be tested by presenting stimuli at the same retinal coordinate with the eye in one of nine different positions. 2) The second experiment will examine visuo-spatial encoding of cingulate neurons to test the idea that these neurons have a preferential role in spatial discrimination. Neural activity will be assessed while monkeys make saccades to spatially aligned cues or to color cues, or view visual stimuli in a passive vision paradigm in which no saccade is made. 3) The third experiment will test the hypothesis that posterior cingulate cortex is a substrate for process underlying working memory. Neural activity will be assessed while monkeys perform the same three tasks of experiment two, but with a mnemonic component. The paradigm will involve a delayed-match-to- sample tasks design for spatial, color or "passive" cues. 4) The fourth experiment will test the hypothesis that posterior cingulate cortex is involved in the control of visual attention. In the first part of this experiment, neuronal activity will be examined during Posner-like tasks in which a reaction measure is used to test for covert shifts of attention. A correlation of neural activity with cue probability conditions will suggest that cingulate neurons may mediate cognitively driven attention. The second part of this experiment will examine the role of cingulate of neurons in spontaneous orienting. A visual stimulus will be given intermittently during a fixation task to determine whether visual responses are stronger on trials in which there is an orienting movement.

描述（根据申请人的摘要改编）：四个系列 提出了实验。 1）初步数据表明后部 扣紧神经元编码轨道位置，扫视方向和 振幅并响应视觉刺激。 第一个系列 实验旨在更全面地表征眼睛运动 相关活动和后扣带回的视觉反应能力 神经元。 猴子将执行一系列任务以识别 与轨道位置，方向和振幅的关系 最佳目标方向。 将测试对视觉反馈的依赖 通过在黑暗中检查出排出。 下一个（EXP 1C）视觉 响应属性将被表征，亮度，亮度和 目标运动方向（棋盘）将有所不同。 在 实验1d。轨道位置对视觉响应能力的影响 将通过在同一视网膜坐标上呈现刺激来测试 九个不同位置之一的眼睛。 2）第二实验 将检查扣带回神经元的视觉空间编码以测试 这些神经元在空间中具有优先作用的想法 歧视。 神经活动将在猴子制作时评估 扫视以空间对齐的提示或彩色提示，或查看视觉 在没有扫视的被动视力范式中的刺激。 3） 第三实验将检验后扣带回的假设 Cortex是用于工作内存的过程的基板。 神经 当猴子执行相同的三个任务时，将评估活动 实验二，但具有助记符成分。 范式将 涉及空间，颜色或 “被动”提示。 4）第四实验将检验以下假设 后扣带回皮质参与视觉的控制 注意力。 在本实验的第一部分中，神经元活动将 在使用反应度量的Posner样任务中检查 测试关注的关注转移。 神经的相关性 具有提示概率条件的活动将表明收获 神经元可能会介导认知驱动的注意力。 第二部分 该实验将检查神经元在 自发定向。 视觉刺激将间歇性地给予 在固定任务中，确定视觉响应是否为 在有方向运动的试验中更强大。