The inferior pulvinar and visual attention

下丘脑和视觉注意力

• 批准号: 7057630
• 负责人: CHRISTIN H MCCOOL
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057630
• 关键词: Macaca mulatta; attention; behavioral /social science research tag; brain electrical activity; brain imaging /visualization /scanning; brain mapping; electrostimulus; neuropsychology; performance; predoctoral investigator; pulvinar thalami; sensory discrimination; stimulus /response; visual cortex; visual perception; visual tracking

DESCRIPTION (provided by applicant): The pulvinar nucleus is richly interconnected with most of visual cortex, leading many to propose a visual role for this enigmatic part of the brain. However, little is known about its role in visual processing. On the basis of lesion, imaging, and recording studies, it has been proposed that pulvinar plays a role in directing visual attention to particular regions of space. In the proposed experiments, we plan to directly examine this hypothesis using electrical microstimulation and reversible inactivation. We will measure both visual detection performance and neuronal responses in extrastriate cortex, with and without perturbation. The detection task will be of a change in motion direction, and we already know that cortical area MT is involved in this kind of perceptual capability. The design allows two distinct comparisons to be made, each critical to this hypothesis. First, we know that directed attention produces behavioral benefits and local changes in the gain of response of extrastriate neurons; activation of pulvinar should mimic this change and reversible inactivation should eliminate it. Also, we will be able to conclude whether the effects measured perceptually could be mediated through known cortical circuits supporting visual discrimination.

描述（由申请人提供）：pulvinar核与大多数视觉皮层息息相关，导致许多人提出了大脑这个神秘部分的视觉作用。但是，对其在视觉处理中的作用知之甚少。在病变，成像和记录研究的基础上，已经提出，Pulvinar在将视觉注意力引向特定空间区域中起着作用。在拟议的实验中，我们计划使用电微刺激和可逆失活直接检查该假设。我们将测量有和不扰动的腹腔外皮质中的视觉检测性能和神经元反应。检测任务将在运动方向上发生变化，我们已经知道皮质区域MT参与了这种感知能力。该设计允许进行两个不同的比较，每个比较对此假设至关重要。首先，我们知道，指示的注意会产生行为益处和局部变化，从而在腹腔外神经元的反应中获得变化。 pulvinar的激活应模仿这种变化，并且可逆失活应消除它。此外，我们将能够通过支持视觉歧视的已知皮层回路来结论是否可以通过知名度介导所测量的效果。