Laminar Organization of Cortical Functional Connectivity in Monkeys

猴子皮质功能连接的层状组织

• 批准号: 9355829
• 负责人: Carl Roger Olson
• 金额: --
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355829
• 关键词: Address; Animals; Area; Attention; Attenuated; Autopsy; Axon; Brain; Cells; Cognition; Cognitive; Cognitive deficits; Data; Delayed Memory; Dependence; Disease; Dorsal; Electrodes; Electroencephalography; Etiology; Exhibits; Fire - disasters; Frequencies; Functional Magnetic Resonance Imaging; Gene Expression; Human; Individual; Instruction; Link; Location; Macaca; Manuals; Measures; Mediating; Memory; Memory impairment; Methodology; Methods; Monitor; Monkeys; Morphology; Motor Cortex; Neurons; Parietal; Parietal Lobe; Pathology; Patients; Phase; Play; Prefrontal Cortex; Process; Property; Pyramidal Cells; Recruitment Activity; Role; Schizophrenia; Short-Term Memory; Signal Transduction; Site; Solid; Source; Surface; Testing; Tissues; Variant; Visual; Visual attention; Work; base; frontal eye fields; in vivo; innovation; lateral intraparietal area; nonhuman primate; research study; sample fixation; sustained attention; visual search; white matter

In tasks requiring attention and working memory, prefrontal and parietal cortex exhibit functional connectivity in the form of oscillatory phase-locking. Project 4 will test the general hypothesis that phase-locking depends on direct connections between the two areas originating from neurons in layer 3. By monitoring electrical activity simultaneously at fine intervals from the cortical surface to the white matter, while monkeys engage in working memory (Aim 1) and attenfion (Aim 2), the experiments will test the speciflc predicfion that signs of funcfional connectivity are maximal in layer 3. By monitoring the electrical activity of identified projection neurons and by examining the impact of blocking projections between the two areas, the experiments will test the specific prediction that direct projections are critical for functional connectivity (Aim 3). Results obtained in Project 4 will have direct relevance to the Central Hypothesis regarding the origin of cognitive deflcits in schizophrenia. This hypothesis states that cognifive deficits arise because pathological changes in layer 3 pyramidal cells interfere with functional connectivity between prefrontal and parietal cortex. Projects 1-3 will focus on the properties of layer 3 pyramidal cells in the healthy brain and in schizophrenia. Project 5 will focus on funcfional connectivity in the healthy brain and in schizophrenia as measured with coherence and causality analyses. The unique contribufion of Project 4 will be to link these domains of inquiry by establishing the role of layer 3 neurons in functional connectivity as assessed with coherence and causality analyses. RELEVANCE (See instructions): This project will establish the role of layer 3 neurons in the cognitive deflcits in schizophrenia.

在需要注意和工作记忆的任务中，前额叶和顶叶皮层具有功能连接性 以振荡性相锁定的形式。项目4将检验一般假设，即相锁取决于 关于第3层神经元的两个区域之间的直接连接。通过监视电气 从皮质表面到白质的精细间隔同时活动，而猴子互动 在工作记忆（AIM 1）和Attenfion（AIM 2）中，实验将测试标志的指定预测 第3层的函数连通性是最大的。 神经元并检查两个区域之间阻塞投影的影响，实验将 测试直接预测对于功能连接至关重要的具体预测（AIM 3）。结果 项目4中获得的与中心假设有关认知的起源直接相关 精神分裂症中的偏好。该假设指出，认知缺陷会出现，因为病理变化 第3层锥体细胞干扰前额叶和顶叶皮层之间的功能连通性。项目 1-3将重点关注健康大脑和精神分裂症中3层锥体细胞的特性。项目5 将重点介绍健康大脑和精神分裂症中的函数连通性，以相干性测量 和因果分析。项目4的独特贡献是将这些查询域链接到 建立第3层神经元在功能连通性中的作用，并具有连贯性和因果关系 分析。 相关性（请参阅说明）： 该项目将确定第3层神经元在精神分裂症的认知偏斜中的作用。