AXONAL SPROUTING AND FUNCTIONAL RECOVERY IN THE CNS

中枢神经系统的轴突萌芽和功能恢复

• 批准号: 3397015
• 负责人: MICHAEL E GOLDBERGER
• 金额: $ 13.11万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-09-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3397015
• 关键词: autonomic reflex; axon; behavior test; cats; chordate locomotion; dorsal root; histochemistry /cytochemistry; mature animal; motor neurons; nervous system regeneration; neural degeneration; neuroanatomy; neurogenesis; neuromuscular transmission; neuronal guidance; newborn animals; proprioception /kinesthesia; psychobiology; sensorimotor system; spinal cord injury; spinal cord surgery; spinal nerves; thalamocortical tract; visceral afferent nerve

THe proposed experiments are designed to investigate the relationship between recovery of motor function following injury to the CNS and the anatomical plasticity specifically collateral sprouting, of the remaining undamaged systems. The methods used will be behavioral and anatomical. The hypothesis underlying these experiments is that converging systems are not equipotential but that they are ordered hierarchically and therefore that the pattern of recovery will be defined by one of the systems which remains. We propose also to examine the relationship between recovery or sparing of function and anatomical plasticity after neonatal lesion to determine to what extent limitations placed on recovery or sprouting develop postnatally.

提出的实验旨在研究关系 在伤害中枢神经系统后运动功能的恢复与 其余的解剖塑性特别是副萌芽 未损坏的系统。 所使用的方法将是行为和解剖学。 这些实验的基础假设是融合系统是 不是等电位，而是在层次上订购，因此 恢复模式将由一个系统定义 遗迹。 我们还建议检查恢复或 新生儿病变后功能和解剖学可塑性的保留 确定对恢复或发芽的限制在多大程度上 产后发展。